Complement in human disease: approved and up-and-coming therapeutics
The complement system is recognised as a protector against blood-borne pathogens and a
controller of immune system and tissue homoeostasis. However, dysregulated complement …
controller of immune system and tissue homoeostasis. However, dysregulated complement …
The good, the bad, and the opportunities of the complement system in neurodegenerative disease
ND Schartz, AJ Tenner - Journal of Neuroinflammation, 2020 - Springer
The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …
Therapeutic targeting of the complement system: from rare diseases to pandemics
P Garred, AJ Tenner, TE Mollnes - Pharmacological reviews, 2021 - Elsevier
The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …
plasma component that “complemented” the antibodies in killing microbes, hence the name …
Structure, function and drug discovery of GPCR signaling
L Cheng, F **a, Z Li, C Shen, Z Yang, H Hou… - Molecular …, 2023 - Springer
G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …
array of physiological processes and responses, such as sensory perception (eg, vision …
[HTML][HTML] Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors
The complement system is a critical part of our innate immune response, and the terminal
products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and …
products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and …
Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis
S Ortiz-Espinosa, X Morales, Y Senent, D Alignani… - Cancer letters, 2022 - Elsevier
Myeloid-derived suppressor cells (MDSCs) play a major role in cancer progression. In this
study, we investigated the mechanisms by which complement C5a increases the capacity of …
study, we investigated the mechanisms by which complement C5a increases the capacity of …
Mechanism of activation and biased signaling in complement receptor C5aR1
The complement system plays an important role in the innate immune response to invading
pathogens. The complement fragment C5a is one of its important effector components and …
pathogens. The complement fragment C5a is one of its important effector components and …
Allosteric modulation of G protein-coupled receptor signaling
G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins,
regulate a wide array of physiological processes in response to extracellular signals …
regulate a wide array of physiological processes in response to extracellular signals …
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors
G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors
(7TMRs), typically interact with two distinct signal-transducers, ie, G proteins and β-arrestins …
(7TMRs), typically interact with two distinct signal-transducers, ie, G proteins and β-arrestins …
C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer's disease mouse model
ND Schartz, HY Liang, K Carvalho, SH Chu… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for
effective, sustainable therapeutic targets is imperative. The complement pathway has been …
effective, sustainable therapeutic targets is imperative. The complement pathway has been …