Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all
mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to …

The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology.
The recent development of powerful tools, including zinc-sensitive fluorescent probes …

Apoptosis is an evolutionarily conserved and tightly regulated cell death pathway.
Physiological cell death is important for maintaining homeostasis and optimal biological …

Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve.
For several decades, we have understood that the RGC death process was executed by …

Our understanding of the roles played by zinc in the physiological and pathological
functioning of the brain is rapidly expanding. The increased availability of genetically …

The pulmonary arteries (PA) in pulmonary arterial hypertension (PAH) are constricted and
remodeled;. They have suppressed apoptosis, partly attributable to suppression of the bone …

Apoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism
utilized by multicellular organisms for disposal of cells that are no longer needed or …

Abstract Voltage-dependent Kv2. 1 K+ channels, which mediate delayed rectifier Kv currents
(IK), are expressed in large clusters on the somata and dendrites of principal pyramidal …

Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …

In a majority of pathophysiological settings, cell death is not accidental—it is controlled by a
complex molecular apparatus. Such a system operates like a computer: it receives several …