There is a high incidence of chromosomal abnormalities in early human embryos, whether
they are generated by natural conception or by assisted reproductive technologies (ART) …

BACKGROUND The genetic composition of embryos generated by in vitro fertilization (IVF)
can be examined with preimplantation genetic testing (PGT). Until recently, PGT was limited …

Correction of disease-causing mutations in human embryos holds the potential to reduce the
burden of inherited genetic disorders and improve fertility treatments for couples with …

Preimplantation genetic testing for aneuploidy (PGT-A) remains one of the most
controversial topics in reproductive medicine. With more than 40% of in vitro fertilization …

Importance Polygenic embryo screening (PES) is a novel technology that estimates the
likelihood of develo** future conditions (eg, diabetes or depression) and traits (eg, height …

Preimplantation genetic testing commonly employs simplistic copy-number analyses to
screen for aneuploidy in blastocyst trophectoderm biopsies. Interpreting intermediate copy …

The increasing proportion of variance in human complex traits explained by polygenic
scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of …

For over 2 decades preimplantation genetic testing (PGT) has been in clinical use to reduce
the risk of miscarriage and genetic disease in patients with advanced maternal age and risk …

Preimplantation genetic testing for aneuploidy (PGT‐A) reduces miscarriage risk, increases
the success of IVF, shortens time to pregnancy, and reduces multiple gestation rates without …

Pregnancy is established during the periconceptional period as a continuum beginning with
blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and …