Network-based drug repositioning
Network-based computational biology, with the emphasis on biomolecular interactions and
omics-data integration, has had success in drug development and created new directions …
omics-data integration, has had success in drug development and created new directions …
Reverse engineering of genome-wide gene regulatory networks from gene expression data
ZP Liu - Current genomics, 2015 - ingentaconnect.com
Transcriptional regulation plays vital roles in many fundamental biological processes.
Reverse engineering of genome-wide regulatory networks from high-throughput …
Reverse engineering of genome-wide regulatory networks from high-throughput …
Identifying critical transitions and their leading biomolecular networks in complex diseases
Identifying a critical transition and its leading biomolecular network during the initiation and
progression of a complex disease is a challenging task, but holds the key to early diagnosis …
progression of a complex disease is a challenging task, but holds the key to early diagnosis …
Detecting tissue-specific early warning signals for complex diseases based on dynamical network biomarkers: study of type 2 diabetes by cross-tissue analysis
Identifying early warning signals of critical transitions during disease progression is a key to
achieving early diagnosis of complex diseases. By exploiting rich information of high …
achieving early diagnosis of complex diseases. By exploiting rich information of high …
Single-sample landscape entropy reveals the imminent phase transition during disease progression
Motivation The time evolution or dynamic change of many biological systems during disease
progression is not always smooth but occasionally abrupt, that is, there is a tip** point …
progression is not always smooth but occasionally abrupt, that is, there is a tip** point …
Coregulation and modulation of NFκB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation
N Fernandez-Jimenez… - Human Molecular …, 2014 - academic.oup.com
It is known that the NFκB route is constitutively upregulated in celiac disease (CD), an
immune-mediated disorder of the gut caused by intolerance to ingested gluten. Our aim was …
immune-mediated disorder of the gut caused by intolerance to ingested gluten. Our aim was …
Identifying critical transitions of complex diseases based on a single sample
Motivation: Unlike traditional diagnosis of an existing disease state, detecting the pre-
disease state just before the serious deterioration of a disease is a challenging task …
disease state just before the serious deterioration of a disease is a challenging task …
Predictive model for inflammation grades of chronic hepatitis B: Large‐scale analysis of clinical parameters and gene expressions
W Zhou, Y Ma, J Zhang, J Hu, M Zhang… - Liver …, 2017 - Wiley Online Library
Background Liver biopsy is the gold standard to assess pathological features (eg
inflammation grades) for hepatitis B virus‐infected patients although it is invasive and …
inflammation grades) for hepatitis B virus‐infected patients although it is invasive and …
Hunt for the tip** point during endocrine resistance process in breast cancer by dynamic network biomarkers
Acquired drug resistance is the major reason why patients fail to respond to cancer
therapies. It is a challenging task to determine the tip** point of endocrine resistance and …
therapies. It is a challenging task to determine the tip** point of endocrine resistance and …
Detecting early-warning signals of type 1 diabetes and its leading biomolecular networks by dynamical network biomarkers
Abstract Background Type 1 diabetes (T1D) is a complex disease and harmful to human
health, and most of the existing biomarkers are mainly to measure the disease phenotype …
health, and most of the existing biomarkers are mainly to measure the disease phenotype …