Epithelial‐mesenchymal transition (EMT) is an important process in embryonic
development, fibrosis, and cancer metastasis. During cancer progression, the activation of …

Unraveling the genetic programs that drive-metastasis may offer insights into how to limit or
prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell …

Understanding how gene regulatory networks control the progressive restriction of cell fates
is a long-standing challenge. Recent advances in measuring gene expression in single cells …

Developmental enhancers initiate transcription and are fundamental to our understanding of
developmental networks, evolution and disease. Despite their importance, the properties …

The metastatic process in breast cancer is related to the expression of the epithelial-to-
mesenchymal transition transcription factors (EMT-TFs) SNAIL, SLUG, SIP1 and TWIST1 …

Metastasis is a multistep process during which cancer cells disseminate from the site of
primary tumors and establish secondary tumors in distant organs. In a search for key …

To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …

Stabilization of the hypoxia-inducible factor-1α (HIF-1α) transcription complex, caused by
intratumoural hypoxia, promotes tumour progression and metastasis, leading to treatment …

The epithelial–mesenchymal transition (EMT), one of the main mechanisms underlying
development of cancer metastasis, induces stem-like properties in epithelial cells. Bmi1 is a …

The increased motility and invasiveness of tumor cells are reminiscent of epithelial-
mesenchymal transition (EMT), which occurs during embryonic development, wound …