Drug discovery is a crucial part of human healthcare and has dramatically benefited human
lifespan and life quality in recent centuries, however, it is usually time-and effort-consuming …

Detergents are indispensable in the isolation of integral membrane proteins from biological
membranes to study their intrinsic structural and functional properties. Solubilization …

Detergents are invaluable tools for studying membrane proteins. However, these
deceptively simple, amphipathic molecules exhibit complex behavior when they self …

The use of detergents for the structural study of membrane proteins is discussed with an
emphasis on practical issues relating to membrane solubilization, protein aggregation …

▪ Abstract Crystallization is necessary to obtain the three-dimensional structure of proteins
and nucleic acids; it often represents the bottleneck in structure determination. Our …

Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in
generating cellular energy and catabolizing tryptophan. Under inflammatory conditions …

Prostaglandin H synthase-1 and-2 (PGHS-1 and-2) catalyze the committed step in
prostaglandin synthesis and are targets for nonsteroidal anti-inflammatory drugs (NSAIDs) …

To obtain protein crystals, researchers must search for conditions in multidimensional
chemical space. Empirically, thousands of crystallization experiments are carried out to …

Five new membrane protein structures have been determined since 1995 using X-ray
crystallography: bacterial light-harvesting complex; bacterial and mitochondrial cytochrome …

The cystic fibrosis transmembrane conductance regulator (CFTR) is responsible for the
disease cystic fibrosis (CF). It is a membrane protein belonging to the ABC transporter family …