Many parasitic worms possess complex and intriguing life cycles, and schistosomes are no
exception. To exit the human body and progress to their successive snail host, Schistosoma …

Schistosomiasis, a chronic neglected tropical disease caused by Schistosoma worms, is
reported in nearly 80 countries. Although the disease affects approximately 260 million …

Exosomes are small vesicles of endocytic origin, which are released into the extracellular
environment and mediate a variety of physiological and pathological conditions. Here we …

Schistosomiasis, caused by a parasitic blood fluke of the genus Schistosoma, is a global
health problem for which new chemotherapeutic options are needed. We explored the …

Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is the
most used, fast, and reproducible method to confirm large-scale gene expression data. The …

Background Serine proteases are important virulence factors for many pathogens. Recently,
we discovered a group of trypsin-like serine proteases with domain organization unique to …

Schistosomiasis, a parasitic disease caused by blood flukes of the genus Schistosoma, is a
global health problem with over 200 million people infected. Treatment relies on just one …

Parasitic nematodes are important and abundant parasites adapted to live a parasitic
lifestyle, with these adaptations all aimed at facilitating their survival and reproduction in …

Azapeptide nitriles are postulated to reversibly covalently react with the active-site cysteine
residue of cysteine proteases and form isothiosemicarbazide adducts. We investigated the …

Fasciolosis is a worldwide parasitic disease of ruminants and an emerging human disease
caused by the liver fluke Fasciola hepatica. The cystatin superfamily of cysteine protease …