Sex-specific differences in lipid and glucose metabolism
Energy metabolism in humans is tuned to distinct sex-specific functions that potentially
reflect the unique requirements in females for gestation and lactation, whereas male …
reflect the unique requirements in females for gestation and lactation, whereas male …
Lipid-induced insulin resistance: unravelling the mechanism
Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …
Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice
We investigated the relationship between gut health, visceral fat dysfunction and metabolic
disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet …
disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet …
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
RA DeFronzo - Diabetologia, 2010 - Springer
Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …
Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial
BH Goodpaster, JP DeLany, AD Otto, L Kuller… - Jama, 2010 - jamanetwork.com
Context The prevalence of severe obesity is increasing markedly, as is prevalence of
comorbid conditions such as hypertension and type 2 diabetes mellitus; however, apart from …
comorbid conditions such as hypertension and type 2 diabetes mellitus; however, apart from …
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
Background Insulin resistance has a causal role in type 2 diabetes. Serum levels of retinol-
binding protein 4 (RBP4), a protein secreted by adipocytes, are increased in insulin-resistant …
binding protein 4 (RBP4), a protein secreted by adipocytes, are increased in insulin-resistant …
[PDF][PDF] Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized …
Although lifestyle interventions are considered the first‐line therapy for nonalcoholic fatty
liver disease (NAFLD), which is extremely common in people with type 2 diabetes, no …
liver disease (NAFLD), which is extremely common in people with type 2 diabetes, no …
Structural and biochemical characteristics of various white adipose tissue depots
A Wronska, Z Kmiec - Acta physiologica, 2012 - Wiley Online Library
It is now widely accepted that white adipose tissue (WAT) is not merely a fuel storage organ,
but also a key component of metabolic homoeostatic mechanisms. Apart from its major role …
but also a key component of metabolic homoeostatic mechanisms. Apart from its major role …
[HTML][HTML] Gender and racial differences in nonalcoholic fatty liver disease
JJ Pan, MB Fallon - World journal of hepatology, 2014 - ncbi.nlm.nih.gov
Due to the worldwide epidemic of obesity, nonalcoholic fatty liver disease (NAFLD) has
become the most common cause of elevated liver enzymes. NAFLD represents a spectrum …
become the most common cause of elevated liver enzymes. NAFLD represents a spectrum …
The role of insulin resistance in nonalcoholic fatty liver disease
KM Utzschneider, SE Kahn - The Journal of Clinical …, 2006 - academic.oup.com
Context: Insulin resistance is an almost universal finding in nonalcoholic fatty liver disease
(NAFLD). This review outlines the evidence linking insulin resistance and NAFLD, explores …
(NAFLD). This review outlines the evidence linking insulin resistance and NAFLD, explores …