It has been a decade since it was discovered that primary cilia have an essential role in
Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that …

Cell cycle investigations have focused on relentless exponential proliferation of cells, an
unsustainable situation in nature. Proliferation of cells, whether microbial or metazoan, is …

In newly hatched Drosophila larvae, quiescent cells reenter the cell cycle in response to
dietary amino acids. To understand this process, we varied larval nutrition and monitored …

Arthropods and vertebrates are constructed of many serially homologous structures whose
individual patterns are regulated by Hox genes. The Hox-regulated target genes and …

Sonic hedgehog is involved in eye field separation along the proximodistal axis. We show
that Hh signalling continues to be important in defining aspects of the proximodistal axis as …

In the avian embryo, previous work has demonstrated that the notochord provides inductive
signals to activate myoD and pax1 regulatory genes, which are expressed in the dorsal and …

Secreted and transmembrane proteins play an essential role in intercellular communication
during the development of multicellular organisms. Because only a small number of these …

An important step in the postgenomic drug discovery is the construction of high quality
chemical libraries that generate bioactive molecules at high rates. Here we report a cell …

Neuronal differentiation in theDrosophilaretinal primordium, the eye imaginal disc, begins at
the posterior tip of the disc and progresses anteriorly as a wave. The morphogenetic furrow …

The Drosophila ommatidia contain two classes of photoreceptor cells (PR's), the outer and
the inner PR's. We performed an enhancer trap screen in order to target genes specifically …