Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at
20 weeks of gestation or later, is a leading cause of perinatal morbidity and mortality …

The complement cascade was identified over 100 years ago, yet investigation of its role in
pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal …

Macrophages are crucial for a successful pregnancy, and malfunctions of decidual
macrophages correlate with adverse pregnancy outcomes, such as spontaneous abortion …

Interleukin‐1 receptor accessory protein (IL‐1RAcP) is a member of the immunoglobulin
superfamily proteins consisting of soluble and membranous isoforms. IL‐1RAcP plays an …

A key immunomodulatory cytokine, IL-10 (interleukin-10), has been shown to be
dysregulated in preeclampsia, a pregnancy-specific hypertensive disorder, further …

Abstract Purpose of Review The pathophysiology of preeclampsia is complex and not
entirely understood. A key feature in preeclampsia development is an immunological …

In vivo studies on the pathology of gestation, including preeclampsia, often use small
mammals such as rabbits or rodents, ie, mice, rats, hamsters, and guinea pigs. The key …

Recent advances have been made in understanding the nature of placental dysfunction
causing preeclampsia, and other hypertensive disorders of pregnancy. The contribution of …

During pregnancy, the maternal host must adapt in order to enable growth of the fetus.
These changes affect all organ systems and are designed both to protect the fetus and to …

Abstract Preeclampsia (PE), a pregnancy‐specific disorder, is a leading cause of perinatal
maternal‐fetal mortality and morbidity. Impaired cell migration and invasion of trophoblastic …