Cannabidiol: pharmacology and therapeutic targets

SC Britch, S Babalonis, SL Walsh - Psychopharmacology, 2021‏ - Springer
Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-
treat a myriad of conditions and for their unsubstantiated health benefits. The scientific …

[HTML][HTML] Towards better delivery of cannabidiol (CBD)

SA Millar, RF Maguire, AS Yates, SE O'Sullivan - Pharmaceuticals, 2020‏ - mdpi.com
Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective
drug by the pharmaceutical industry is hindered by intrinsic characteristics such as low …

Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems

J Moltke, C Hindocha - Journal of cannabis research, 2021‏ - Springer
Background Public and medical interest in cannabidiol (CBD) has been rising, and CBD is
now available from various sources. Research into the effects of low-dose CBD on outcomes …

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions

S Nasrin, CJW Watson, YX Perez-Paramo… - Drug Metabolism and …, 2021‏ - Elsevier
The legalization of cannabis in many parts of the United States and other countries has led
to a need for a more comprehensive understanding of cannabis constituents and their …

[HTML][HTML] Determining the magnitude and duration of acute Δ9-tetrahydrocannabinol (Δ9-THC)-induced driving and cognitive impairment: A systematic and meta …

D McCartney, TR Arkell, C Irwin, IS McGregor - … & Biobehavioral Reviews, 2021‏ - Elsevier
The increasing legal availability of cannabis has important implications for road safety. This
systematic review characterised the acute effects of Δ 9-THC on driving performance and …

Effect of Cannabidiol and Δ9-Tetrahydrocannabinol on Driving Performance: A Randomized Clinical Trial

TR Arkell, F Vinckenbosch, RC Kevin, EL Theunissen… - Jama, 2020‏ - jamanetwork.com
Importance Cannabis use has been associated with increased crash risk, but the effect of
cannabidiol (CBD) on driving is unclear. Objective To determine the driving impairment …

The safety and efficacy of low oral doses of cannabidiol: an evaluation of the evidence

JC Arnold, D McCartney, A Suraev… - Clinical and …, 2023‏ - Wiley Online Library
Global interest in the non‐intoxicating cannabis constituent, cannabidiol (CBD), is
increasing with claims of therapeutic effects across a diversity of health conditions. At …

Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies

AS Suraev, NS Marshall, R Vandrey, D McCartney… - Sleep medicine …, 2020‏ - Elsevier
Cannabinoids, including the two main phytocannabinoids Δ 9-tetrahydrocannabinol (THC)
and cannabidiol (CBD), are being increasingly utilised as pharmacological interventions for …

Cannabinoids, endocannabinoids and sleep

AJ Kesner, DM Lovinger - Frontiers in molecular neuroscience, 2020‏ - frontiersin.org
Sleep is a vital function of the nervous system that contributes to brain and bodily
homeostasis, energy levels, cognitive ability, and other key functions of a variety of …

Evaluation of cytochrome P450‐mediated cannabinoid‐drug interactions in healthy adult participants

S Bansal, CA Zamarripa, TR Spindle… - Clinical …, 2023‏ - Wiley Online Library
Understanding cannabis‐drug interactions is critical given regulatory changes that have
increased access to and use of cannabis. Cannabidiol (CBD) and Δ‐9 …