How does adenosine control neuronal dysfunction and neurodegeneration?
RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
G protein–coupled receptor oligomerization revisited: functional and pharmacological perspectives
Most evidence indicates that, as for family CG protein–coupled receptors (GPCRs), family A
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
Adenosine receptors: expression, function and regulation
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …
mediate the physiological actions of adenosine. To date, four AR subtypes have been …
Organization and functions of mGlu and GABAB receptor complexes
The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals
by activating fast-acting ligand-gated ion channels and more slowly acting G-protein …
by activating fast-acting ligand-gated ion channels and more slowly acting G-protein …
Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences
S Aringhieri, M Carli, S Kolachalam, V Verdesca… - Pharmacology & …, 2018 - Elsevier
The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …
G protein–coupled receptor heteromers
G protein–coupled receptors (GPCRs) compose one of the largest families of membrane
proteins involved in intracellular signaling. They are involved in numerous physiological and …
proteins involved in intracellular signaling. They are involved in numerous physiological and …
A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
G‐protein‐coupled receptors (GPCRs) can form heteromeric complexes. Herein'we describe
a new approach to test the heteromerization of 2 receptors' or 2 receptor subunits' and to …
a new approach to test the heteromerization of 2 receptors' or 2 receptor subunits' and to …
[HTML][HTML] Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum
Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …
dopaminergic neurotransmission. In the present essay we first review the extensive …
Understanding wiring and volume transmission
The proposal on the existence of two main modes of intercellular communication in the
central nervous system (CNS) was introduced in 1986 and called wiring transmission (WT) …
central nervous system (CNS) was introduced in 1986 and called wiring transmission (WT) …
Allostery at G protein-coupled receptor homo-and heteromers: uncharted pharmacological landscapes
For many years seven transmembrane domain G protein-coupled receptors (GPCRs) were
thought to exist and function exclusively as monomeric units. However, evidence both from …
thought to exist and function exclusively as monomeric units. However, evidence both from …