Cisplatin: The first metal based anticancer drug

S Ghosh - Bioorganic chemistry, 2019 - Elsevier
Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

JS Suk, Q Xu, N Kim, J Hanes, LM Ensign - Advanced drug delivery reviews, 2016 - Elsevier
Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a
commonly used approach for improving the efficiency of drug and gene delivery to target …

Engineered nanoparticles for drug delivery in cancer therapy

T Sun, YS Zhang, B Pang, DC Hyun… - Nanomaterials and …, 2021 - taylorfrancis.com
In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve a
number of issues associated with conventional therapeutic agents, including their poor …

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

HK Makadia, SJ Siegel - Polymers, 2011 - mdpi.com
In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive
polymeric candidates used to fabricate devices for drug delivery and tissue engineering …

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

E Pérez-Herrero, A Fernández-Medarde - European journal of …, 2015 - Elsevier
Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …

PLGA-based nanoparticles: an overview of biomedical applications

F Danhier, E Ansorena, JM Silva, R Coco… - Journal of controlled …, 2012 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successfully developed
biodegradable polymers. Among the different polymers developed to formulate polymeric …

The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials

L Zeng, P Gupta, Y Chen, E Wang, L Ji… - Chemical Society …, 2017 - pubs.rsc.org
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …

Aptamers as therapeutics

AD Keefe, S Pai, A Ellington - Nature reviews Drug discovery, 2010 - nature.com
Nucleic acid aptamers can be selected from pools of random-sequence oligonucleotides to
bind a wide range of biomedically relevant proteins with affinities and specificities that are …

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

N Kamaly, Z **ao, PM Valencia… - Chemical Society …, 2012 - pubs.rsc.org
Polymeric materials have been used in a range of pharmaceutical and biotechnology
products for more than 40 years. These materials have evolved from their earlier use as …

Metallodrugs in cancer nanomedicine

Q Peña, A Wang, O Zaremba, Y Shi… - Chemical society …, 2022 - pubs.rsc.org
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …