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Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells
SL Geng, XJ Zhao, X Zhang, JH Zhang, CL Mi… - Applied Microbiology …, 2024 - Springer
Mammalian cell lines are frequently used as the preferred host cells for producing
recombinant therapeutic proteins (RTPs) having post-translational modified modification …
recombinant therapeutic proteins (RTPs) having post-translational modified modification …
Advances in serum‐free media for CHO cells: From traditional serum substitutes to microbial‐derived substances
M Zhang, X Zhao, Y Li, Q Ye, Y Wu, Q Niu… - Biotechnology …, 2024 - Wiley Online Library
The Chinese hamster ovary (CHO) cell is an epithelial‐like cell that produces proteins with
post‐translational modifications similar to human glycosylation. It is widely used in the …
post‐translational modifications similar to human glycosylation. It is widely used in the …
Current strategies for the development of high-yield HEK293 cell lines
L Zhang, J Gao, X Zhang, X Wang, T Wang… - Biochemical Engineering …, 2024 - Elsevier
At present, approximately 80% of the currently approved recombinant therapeutic proteins
are produced by Chinese hamster ovary cells. However, considering that the human …
are produced by Chinese hamster ovary cells. However, considering that the human …
Optimization of a novel expression system for recombinant protein production in CHO cells
J Zhang, C Du, Y Pan, Z Zhang, R Feng, M Ma… - Scientific Reports, 2024 - nature.com
Chinese hamster ovary (CHO) cells are common mammalian cell lines for expressing
recombinant proteins, yet the expression level of recombinant proteins is still hindered …
recombinant proteins, yet the expression level of recombinant proteins is still hindered …
Effects of the COVID-19 pandemic: new approaches for accelerated delivery of gene to first-in-human CMC data for recombinant proteins
H Broly, J Souquet, A Beck - MAbs, 2023 - Taylor & Francis
The COVID-19 pandemic highlighted the urgent need for life-saving treatments, including
vaccines, drugs, and therapeutic antibodies, delivered at unprecedented speed. During this …
vaccines, drugs, and therapeutic antibodies, delivered at unprecedented speed. During this …
[HTML][HTML] Characterization of Proliferation Medium and Its Effect on Differentiation of Muscle Satellite Cells from Larimichthys crocea in Cultured Fish Meat Production
S Zhang, H Lou, H Lu, E Xu, D Liu, Q Chen - Fishes, 2023 - mdpi.com
To find a suitable medium for muscle satellite cells of Larimichthys crocea, herein, the effect
of different basal media and coating materials on the proliferation of piscine satellite cells …
of different basal media and coating materials on the proliferation of piscine satellite cells …
SiMPl‐GS: Advancing Cell Line Development via Synthetic Selection Marker for Next‐Generation Biopharmaceutical Production
C Yoon, E Lee, D Kim, S Joung, Y Kim… - Advanced …, 2024 - Wiley Online Library
Rapid and efficient cell line development (CLD) process is essential to expedite therapeutic
protein development. However, the performance of widely used glutamine‐based selection …
protein development. However, the performance of widely used glutamine‐based selection …