Targeting the cell cycle: a new approach to cancer therapy
GK Schwartz, MA Shah - Journal of clinical oncology, 2005 - ascopubs.org
The cell cycle represents a series of tightly integrated events that allow the cell to grow and
proliferate. Critical parts of the cell cycle machinery are the cyclin-dependent kinases …
proliferate. Critical parts of the cell cycle machinery are the cyclin-dependent kinases …
Cell cycle-dependent transcription: the cyclin dependent kinase Cdk1 is a direct regulator of basal transcription machineries
The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the
cell cycle. It phosphorylates several key proteins to control progression through the different …
cell cycle. It phosphorylates several key proteins to control progression through the different …
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II–dependent transcription and down-regulation of …
DE MacCallum, J Melville, S Frame, K Watt… - Cancer research, 2005 - AACR
Abstract Seliciclib (CYC202, R-roscovitine) is a cyclin-dependent kinase (CDK) inhibitor that
competes for the ATP binding site on the kinase. It has greatest activity against CDK2/cyclin …
competes for the ATP binding site on the kinase. It has greatest activity against CDK2/cyclin …
CAK—cyclin-dependent activating kinase: a key kinase in cell cycle control and a target for drugs?
G Lolli, LN Johnson - Cell cycle, 2005 - Taylor & Francis
The Cyclin-dependent kinase (CDK) Activating Kinase (CAK) is responsible for the
activating phosphorylation of CDK1, CDK2, CDK4 and CDK6 and regulation of the cell …
activating phosphorylation of CDK1, CDK2, CDK4 and CDK6 and regulation of the cell …
HIV-1 TAR RNA: the target of molecular interactions between the virus and its host
S Bannwarth, A Gatignol - Current HIV research, 2005 - ingentaconnect.com
HIV-1 TAR RNA is the binding site of the viral protein Tat, the trans-activator of the HIV-1
LTR. It is present at the 5'end of all HIV-1 spliced and unspliced mRNAs in the nucleus as …
LTR. It is present at the 5'end of all HIV-1 spliced and unspliced mRNAs in the nucleus as …
Investigating RNA polymerase II carboxyl‐terminal domain (CTD) phosphorylation
B Palancade, O Bensaude - European Journal of Biochemistry, 2003 - Wiley Online Library
Phosphorylation of RNA polymerase II's largest subunit C‐terminal domain (CTD) is a key
event during mRNA metabolism. Numerous enzymes, including cell cycle‐dependent …
event during mRNA metabolism. Numerous enzymes, including cell cycle‐dependent …
Genetic variation and function of the HIV-1 Tat protein
Human immunodeficiency virus type 1 (HIV-1) encodes a transactivator of transcription (Tat)
protein, which has several functions that promote viral replication, pathogenesis, and …
protein, which has several functions that promote viral replication, pathogenesis, and …
CDK11 complexes promote pre-mRNA splicing
The PITSLRE protein kinases, hereafter referred to as CDK11 because of their association
with the cyclin L regulatory partner, belong to large molecular weight protein complexes that …
with the cyclin L regulatory partner, belong to large molecular weight protein complexes that …
Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells
D Cai, VM Latham Jr, X Zhang, GI Shapiro - Cancer research, 2006 - AACR
Selective cyclin-dependent kinase (cdk) 2 inhibition is readily compensated. However,
reduced cdk2 activity may have antiproliferative effects in concert with other family members …
reduced cdk2 activity may have antiproliferative effects in concert with other family members …
Tat gets the" green" light on transcription initiation
J Brady, F Kashanchi - Retrovirology, 2005 - Springer
Human immunodeficiency virus type 1 (HIV-1) Tat transactivation is an essential step in the
viral life cycle. Over the past several years, it has become widely accepted that Tat exerts its …
viral life cycle. Over the past several years, it has become widely accepted that Tat exerts its …