High-density lipoproteins: nature's multifunctional nanoparticles

R Kuai, D Li, YE Chen, JJ Moon, A Schwendeman - ACS nano, 2016 - ACS Publications
High-density lipoproteins (HDL) are endogenous nanoparticles involved in the transport and
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …

Nanocarrier‐mediated cytosolic delivery of biopharmaceuticals

W He, X **ng, X Wang, D Wu, W Wu… - Advanced functional …, 2020 - Wiley Online Library
Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics

Y Sun, SY Lau, ZW Lim, SC Chang, F Ghadessy… - Nature Chemistry, 2022 - nature.com
Biomacromolecules are highly promising therapeutic modalities to treat various diseases.
However, they suffer from poor cellular membrane permeability, limiting their access to …

Phase-separating peptide coacervates with programmable material properties for universal intracellular delivery of macromolecules

Y Sun, X Wu, J Li, M Radiom, R Mezzenga… - Nature …, 2024 - nature.com
Phase-separating peptides (PSPs) self-assembling into coacervate microdroplets (CMs) are
a promising class of intracellular delivery vehicles that can release macromolecular …

Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy

Y Qian, H **, S Qiao, Y Dai, C Huang, L Lu, Q Luo… - Biomaterials, 2016 - Elsevier
The design of peptide-based subunit vaccine formulations for the direct delivery of tumor
antigen peptides (Aps) to dendritic cells (DCs) localized within draining lymph nodes (DLNs) …

Intracellular delivery of nanocarriers and targeting to subcellular organelles

A Jhaveri, V Torchilin - Expert opinion on drug delivery, 2016 - Taylor & Francis
Introduction: Recent trends in drug delivery indicate a steady increase in the use of targeted
therapeutics to enhance the specific delivery of biologically active payloads to diseased …

Lipid-based nanoparticles in the systemic delivery of siRNA

Q Lin, J Chen, Z Zhang, G Zheng - Nanomedicine, 2014 - Taylor & Francis
RNAi therapeutics are believed to be the future of personalized medicine and have shown
promise in early clinical trials. However, many physiological barriers exist in the systemic …

Direct cytosolic delivery of siRNA using nanoparticle‐stabilized Nanocapsules

Y Jiang, R Tang, B Duncan, Z Jiang, B Yan… - Angewandte …, 2015 - Wiley Online Library
The use of nanoparticle‐stabilized nanocapsules (NPSCs) for the direct cytosolic delivery of
siRNA is reported. In this approach, siRNA is complexed with cationic arginine …

Reconstituted high density lipoprotein (rHDL), a versatile drug delivery nanoplatform for tumor targeted therapy

Y Mei, L Tang, Q **ao, Z Zhang, Z Zhang… - Journal of Materials …, 2021 - pubs.rsc.org
rHDL is a synthesized drug delivery nanoplatform exhibiting excellent biocompatibility,
which possesses most of the advantages of HDL. rHDL shows almost no toxicity and can be …

Targeted biomimetic nanoparticles for synergistic combination chemotherapy of paclitaxel and doxorubicin

M Rui, Y **n, R Li, Y Ge, C Feng, X Xu - Molecular pharmaceutics, 2017 - ACS Publications
Codelivery of multiple chemotherapeutics has become a versatile strategy in recent cancer
treatment, but the antagonistic behavior of combined drugs limited their application. We …