High-density lipoproteins: nature's multifunctional nanoparticles
High-density lipoproteins (HDL) are endogenous nanoparticles involved in the transport and
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …
Nanocarrier‐mediated cytosolic delivery of biopharmaceuticals
Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …
promise in the rapidly expanding pharmaceutical market due to their high specificity and …
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics
Biomacromolecules are highly promising therapeutic modalities to treat various diseases.
However, they suffer from poor cellular membrane permeability, limiting their access to …
However, they suffer from poor cellular membrane permeability, limiting their access to …
Phase-separating peptide coacervates with programmable material properties for universal intracellular delivery of macromolecules
Phase-separating peptides (PSPs) self-assembling into coacervate microdroplets (CMs) are
a promising class of intracellular delivery vehicles that can release macromolecular …
a promising class of intracellular delivery vehicles that can release macromolecular …
Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy
The design of peptide-based subunit vaccine formulations for the direct delivery of tumor
antigen peptides (Aps) to dendritic cells (DCs) localized within draining lymph nodes (DLNs) …
antigen peptides (Aps) to dendritic cells (DCs) localized within draining lymph nodes (DLNs) …
Intracellular delivery of nanocarriers and targeting to subcellular organelles
Introduction: Recent trends in drug delivery indicate a steady increase in the use of targeted
therapeutics to enhance the specific delivery of biologically active payloads to diseased …
therapeutics to enhance the specific delivery of biologically active payloads to diseased …
Lipid-based nanoparticles in the systemic delivery of siRNA
RNAi therapeutics are believed to be the future of personalized medicine and have shown
promise in early clinical trials. However, many physiological barriers exist in the systemic …
promise in early clinical trials. However, many physiological barriers exist in the systemic …
Direct cytosolic delivery of siRNA using nanoparticle‐stabilized Nanocapsules
The use of nanoparticle‐stabilized nanocapsules (NPSCs) for the direct cytosolic delivery of
siRNA is reported. In this approach, siRNA is complexed with cationic arginine …
siRNA is reported. In this approach, siRNA is complexed with cationic arginine …
Reconstituted high density lipoprotein (rHDL), a versatile drug delivery nanoplatform for tumor targeted therapy
Y Mei, L Tang, Q **ao, Z Zhang, Z Zhang… - Journal of Materials …, 2021 - pubs.rsc.org
rHDL is a synthesized drug delivery nanoplatform exhibiting excellent biocompatibility,
which possesses most of the advantages of HDL. rHDL shows almost no toxicity and can be …
which possesses most of the advantages of HDL. rHDL shows almost no toxicity and can be …
Targeted biomimetic nanoparticles for synergistic combination chemotherapy of paclitaxel and doxorubicin
M Rui, Y **n, R Li, Y Ge, C Feng, X Xu - Molecular pharmaceutics, 2017 - ACS Publications
Codelivery of multiple chemotherapeutics has become a versatile strategy in recent cancer
treatment, but the antagonistic behavior of combined drugs limited their application. We …
treatment, but the antagonistic behavior of combined drugs limited their application. We …