Episodic memory and working memory decline with advancing age. Nevertheless, large-
scale population-based studies document well-preserved memory functioning in some older …

Human cognitive aging differs between and is malleable within individuals. In the absence
of a strong genetic program, it is open to a host of hazards, such as vascular conditions …

Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although
there are multiple paths by which hippocampal deterioration occurs in late life, the authors …

Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development,
differentiation and plasticity in both the develo** and adult brain. A single-nucleotide …

Similar to other industrialized countries, Germany's population is ageing. Whereas some
people enjoy good physical and cognitive health into old age, others suffer from a multitude …

Associations between genotypes and cognitive outcomes may provide clues as to which
mechanisms cause individual differences in old-age cognitive performance. We investigated …

Brain derived neurotrophic factor (BDNF) is a critical component of the molecular
mechanism of memory formation. Variation in the BDNF gene, particularly the rs6265 …

Favored by increased life expectancy and reduced birth rate, worldwide demography is
rapidly shifting to older ages. The golden age of aging is not only an achievement but also a …

Many aspects of cognition decline from middle to late adulthood, but the dimensionality and
generality of this decline have rarely been examined. We analyzed 20-year longitudinal data …

Heritability studies document substantial genetic influences on cognitive performance and
decline in old age. Increasing evidence shows that effects of genetic variations on cognition …