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Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy
Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …
[HTML][HTML] Cellular models and in vitro assays for the screening of modulators of P-gp, MRP1 and BCRP
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are highly expressed in
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …
Age-related functional and expressional changes in efflux pathways at the blood-brain barrier
During the last decade, several articles have reported a relationship between advanced age
and changes in the integrity of the blood-brain barrier (BBB). These changes were …
and changes in the integrity of the blood-brain barrier (BBB). These changes were …
A rationale for age-adapted immunosuppression in organ transplantation
Demographic changes are associated with a steady increase of older patients with end-
stage organ failure in need for transplantation. As a result, the majority of transplant …
stage organ failure in need for transplantation. As a result, the majority of transplant …
Age-mediated changes in the gastrointestinal tract
Physiological functions of the two extreme ends of the age spectrum, children (< 18 y old)
and older adults (aged 65 y and over), differ from healthy young adults. This consequently …
and older adults (aged 65 y and over), differ from healthy young adults. This consequently …
[HTML][HTML] Study models of drug–drug interactions involving p-glycoprotein: the potential benefit of p-glycoprotein modulation at the kidney and intestinal levels
P-glycoprotein (P-gp) is a crucial membrane transporter situated on the cell's apical surface,
being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are …
being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are …
P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity
The induction of P-glycoprotein (P-gp), an ATP-dependent efflux pump, has been proposed
as a strategy against the toxicity induced by P-gp substrates such as the herbicide paraquat …
as a strategy against the toxicity induced by P-gp substrates such as the herbicide paraquat …
Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: In Vitro, Ex Vivo, and In Silico Studies
P-glycoprotein (P-gp) plays a crucial role in the protection of susceptible organs, by
significantly decreasing the absorption/distribution of harmful xenobiotics and, consequently …
significantly decreasing the absorption/distribution of harmful xenobiotics and, consequently …
Longitudinal pharmacokinetics of tacrolimus in elderly compared with younger recipients in the first 6 months after renal transplantation
Background Elderly (Eld)(≥ 60 years) recipients are receiving renal transplants more
frequently. The pharmacokinetics (PK) studies of immunosuppressive drugs in healthy …
frequently. The pharmacokinetics (PK) studies of immunosuppressive drugs in healthy …
Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat
Xanthones are a family of compounds with several known biological activities and
therapeutic potential for which information on their interaction with membrane transporters is …
therapeutic potential for which information on their interaction with membrane transporters is …