Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of
the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids …

Tumors are being increasingly perceived as abnormal organs that, in many respects,
recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea …

Growth of numerous cancer types is believed to be driven by a subpopulation of poorly
differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for …

Angiogenesis is one of the critical biological elements affecting the development and
progression of cancer. Long non-coding RNAs (lncRNAs) are important regulators and …

Hypoxia is implicated in many aspects of tumor development, angiogenesis, and growth in
many different tumors. Brain tumors, particularly the highly aggressive glioblastoma …

The poor response of glioblastoma to current treatment protocols is a consequence of its
intrinsic drug resistance. Resistance to chemotherapy is primarily associated with …

DNA double-strand breaks (DSBs) can efficiently kill cancer cells, but they can also produce
unwanted chromosome rearrangements when DNA ends from different DSBs are …

Increased need for glycolysis and glucose uptake for ATP production is observed in tumor
cells, particularly in cells lacking of oxygen supply. Because glucose is transported from …

Hypoxia plays an important role in vascular development through hypoxia-inducible factor-
1α (HIF-1α) accumulation and downstream pathway activation. We sought to explore the in …

Despite major improvements in the surgical management the prognosis for patients bearing
malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment …