RNA dysregulation in neurodegenerative diseases
Y Li, S Sun - The EMBO Journal, 2025 - embopress.org
Dysregulation of RNA processing has in recent years emerged as a significant contributor to
neurodegeneration. The diverse mechanisms and molecular functions underlying RNA …
neurodegeneration. The diverse mechanisms and molecular functions underlying RNA …
Amyotrophic lateral sclerosis represents corticomotoneuronal system failure
Several decades have passed since the anterograde corticomotoneuronal hypothesis for
amyotrophic lateral sclerosis (ALS) was proposed. The intervening years have witnessed its …
amyotrophic lateral sclerosis (ALS) was proposed. The intervening years have witnessed its …
TDP‐43 Cryptic RNAs in Perry Syndrome: Differences across Brain Regions and TDP‐43 Proteinopathies
SR Pickles, J Gonzalez Bejarano… - Movement …, 2025 - Wiley Online Library
Background Perry syndrome (PS) is a rare and fatal hereditary autosomal dominant
neurodegenerative disorder caused by mutations in dynactin (DCTN1). PS brains …
neurodegenerative disorder caused by mutations in dynactin (DCTN1). PS brains …
A phase Ib/IIa randomized trial of Enoxacin in patients with ALS
Abstract Background and Objectives The RNAse III DICER is essential for miRNA
biogenesis. DICER activity is downregulated in sporadic and genetic forms of ALS …
biogenesis. DICER activity is downregulated in sporadic and genetic forms of ALS …
[PDF][PDF] Analysis of the therapeutic strategies used to treat Amyotrophic Lateral Sclerosis caused by TDP-43 aggregation and/or mislocalization
S Sar - Journal of High School Science, 2024 - jhss.scholasticahq.com
Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disorder that impairs motor
functions, affects 1 in 50,000 people in the world, and has an insignificant hereditary …
functions, affects 1 in 50,000 people in the world, and has an insignificant hereditary …