Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …

Systemic and local chronic inflammation might enhance the risk of pancreatic ductal
adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor …

Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

Plenty of immune cells infiltrate into the tumor microenvironment (TME) during tumor
progression, in which myeloid-derived suppressor cells (MDSCs) represent a …

Exosomes are a class of small membrane-bound extracellular vesicles released by almost
all cell types and present in all body fluids. Based on the studies of exosome content and …

Pancreatic cancer (PC) is the most lethal malignancy worldwide due to its delayed diagnosis
and limited treatment options. Despite great progress in clinical trials of immunotherapies for …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive
malignancies to date, largely because it is associated with high metastatic risk. Pancreatic …

Pancreatic cancer has the worst prognosis among common tumors which is attributed to its
aggressive phenotype, diagnosis at advanced, inoperable stages, and resistance to …

Pancreatic ductal adenocarcinoma (PDAC) interacts closely with the tumor
microenvironment (TME). The TME is remodeled by crosstalk between pancreatic cancer …