[HTML][HTML] Pathology and pathogenesis of metabolic dysfunction-associated steatotic liver disease-associated hepatic tumors

Y Takahashi, E Dungubat, H Kusano, T Fukusato - Biomedicines, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation in
the livers of patients without a history of alcohol abuse. It is classified as either simple …

miR-22 gene therapy treats HCC by promoting anti-tumor immunity and enhancing metabolism

Y Hu, T Setayesh, F Vaziri, X Wu, ST Hwang, X Chen… - Molecular Therapy, 2023 - cell.com
MicroRNA-22 (miR-22) can be induced by beneficial metabolites that have metabolic and
immune effects, including retinoic acids, bile acids, vitamin D 3, and short-chain fatty acids …

[HTML][HTML] Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma

T Setayesh, SD Colquhoun, YJY Wan - Liver research, 2020 - Elsevier
Galectins (Gals) are evolutionarily conserved proteins that bind to β-galactoside containing
glycans. Abnormal expression of Gals is associated with the development, progression, and …

Hsa-miR-22-3p inhibits liver cancer cell EMT and cell migration/invasion by indirectly regulating SPRY2

S Cui, Y Chen, Y Guo, X Wang, D Chen - PLoS One, 2023 - journals.plos.org
The general mechanism for microRNAs to play biological function is through their inhibition
on the expression of their target genes. In cancer, microRNAs may accelerate cell …

MicroRNA-22-3p displaces critical host factors from the 5′ UTR and inhibits the translation of Coxsackievirus B3 RNA

P Rani, B George, SV, S Biswas, MV, A Pal… - Journal of …, 2024 - journals.asm.org
ABSTRACT Coxsackievirus B3 (CVB3) is known to cause acute myocarditis and pancreatitis
in humans. We investigated the microRNAs (miRNAs) that can potentially govern the viral …

[HTML][HTML] Free fatty acid-induced miR-22 inhibits gluconeogenesis via SIRT-1-mediated PGC-1α expression in nonalcoholic fatty liver disease

AK Yadav, TN Sata, D Verma, AK Sah, AK Mishra… - iLIVER, 2023 - Elsevier
A bstract Background and aims Free fatty acids (FFAs) are one of the important regulators of
the progression of nonalcoholic fatty liver disease. The FFAs are shown to modulate the …

An immunocompetent environment unravels the proto-oncogenic role of miR-22

ML Centomo, M Vitiello, L Poliseno, PP Pandolfi - Cancers, 2022 - mdpi.com
Simple Summary Through their regulatory activity of gene expression, microRNAs have
been heavily implicated in the genesis of cancer. They can act both as promoters …

[HTML][HTML] MiR-22 deficiency fosters hepatocellular carcinoma development in fatty liver

M Gjorgjieva, AS Ay, M Correia de Sousa, E Delangre… - Cells, 2022 - mdpi.com
MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro
analyses. Yet, whether miR-22 exerts a tumor-suppressive function in the liver has not been …

[HTML][HTML] The Role of microRNA-22 in Metabolism

S Tomasini, P Vigo, F Margiotta… - International …, 2025 - pmc.ncbi.nlm.nih.gov
microRNA-22 (miR-22) plays a pivotal role in the regulation of metabolic processes and has
emerged as a therapeutic target in metabolic disorders, including obesity, type 2 diabetes …

Evaluation of the relationship between miRNA-22-3p and Gal-9 levels in glioblastoma

Z Barut, FT Akdeniz - in vivo, 2023 - iv.iiarjournals.org
Background/Aim: Glioblastoma, the most prevalent primary malignant brain tumor, is
significantly impacted by molecular mechanisms, including the function of microRNAs and …