Breast cancer is one of the leading causes of mortality in females. Over the past decades,
intensive efforts have been made to uncover the pathogenesis of breast cancer. Interleukin …

Tumors that express detectable levels of the product of the ESR1 gene (estrogen receptor-α;
ERα) represent the single largest molecular subtype of breast cancer. More women …

Tamoxifen, an estrogen receptor (ER) antagonist, is the mainstay treatment of breast cancer
and the development of resistance represents a major obstacle for a cure. Although long …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the
genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α) …

The molecular mechanisms underlying estrogen receptor (ER)‐positive breast
carcinogenesis and endocrine therapy resistance remain incompletely understood. Here …

Breast cancer is the most prevalent malignancy among women. Although endocrine therapy
is effective, the development of endocrine resistance is a major clinical challenge. The tumor …

Cosmetics are a source of lifetime exposure to various substances including parabens,
being the most popular synthetic preservatives. Because the use of cosmetics shows an …

This toxicology update reviews research over the past four years since publication in 2004 of
the first measurement of intact esters of p‐hydroxybenzoic acid (parabens) in human breast …

The unfolded protein response (UPR) is a stress response activated by the accumulation of
unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its …