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Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis
QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
Inflammation and reactive oxygen species as disease modifiers in epilepsy
G Terrone, S Balosso, A Pauletti, T Ravizza… - …, 2020 - Elsevier
Neuroinflammation and reactive oxygen and nitrogen species are rapidly induced in the
brain after acute cerebral injuries that are associated with an enhanced risk for epilepsy in …
brain after acute cerebral injuries that are associated with an enhanced risk for epilepsy in …
Pathophysiological responses and roles of astrocytes in traumatic brain injury
S Michinaga, Y Koyama - International journal of molecular sciences, 2021 - mdpi.com
Traumatic brain injury (TBI) is immediate damage caused by a blow to the head resulting
from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in …
from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in …
The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …
of neuroinflammation in the injured brain following trauma. We summarise the literature …
Role of HMGB1/TLR4 and IL-1β/IL-1R1 signaling pathways in epilepsy
S Zhang, F Chen, F Zhai, S Liang - Frontiers in Neurology, 2022 - frontiersin.org
Epilepsy is a chronic disorder of the nervous system characterized by recurrent seizures.
Inflammation is one of the six major causes of epilepsy, and its role in the pathogenesis of …
Inflammation is one of the six major causes of epilepsy, and its role in the pathogenesis of …
Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy
Survivors of traumatic brain injury (TBI) often develop chronic neurological, neurocognitive,
psychological, and psychosocial deficits that can have a profound impact on an individual's …
psychological, and psychosocial deficits that can have a profound impact on an individual's …
Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …
Functional deficiency in endogenous interleukin‐1 receptor antagonist in patients with febrile infection‐related epilepsy syndrome
BDS Clarkson, RG LaFrance‐Corey… - Annals of …, 2019 - Wiley Online Library
Objective We recently reported successful treatment of a child with febrile infection‐related
epilepsy syndrome (FIRES), a subtype of new onset refractory status epilepticus, with the …
epilepsy syndrome (FIRES), a subtype of new onset refractory status epilepticus, with the …
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis
Posttraumatic epilepsy (PTE) is a well‐known chronic complication following traumatic brain
injury (TBI). Despite some evidence that age at the time of injury may influence the likelihood …
injury (TBI). Despite some evidence that age at the time of injury may influence the likelihood …
Pharmacological targeting of brain inflammation in epilepsy: Therapeutic perspectives from experimental and clinical studies
T Ravizza, A Vezzani - Epilepsia open, 2018 - Wiley Online Library
Increasing evidence supports a pathogenic role of unabated neuroinflammation in various
central nervous system (CNS) diseases, including epilepsy. Neuroinflammation is not a …
central nervous system (CNS) diseases, including epilepsy. Neuroinflammation is not a …