Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis

QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Inflammation and reactive oxygen species as disease modifiers in epilepsy

G Terrone, S Balosso, A Pauletti, T Ravizza… - …, 2020 - Elsevier
Neuroinflammation and reactive oxygen and nitrogen species are rapidly induced in the
brain after acute cerebral injuries that are associated with an enhanced risk for epilepsy in …

Pathophysiological responses and roles of astrocytes in traumatic brain injury

S Michinaga, Y Koyama - International journal of molecular sciences, 2021 - mdpi.com
Traumatic brain injury (TBI) is immediate damage caused by a blow to the head resulting
from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in …

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …

Role of HMGB1/TLR4 and IL-1β/IL-1R1 signaling pathways in epilepsy

S Zhang, F Chen, F Zhai, S Liang - Frontiers in Neurology, 2022 - frontiersin.org
Epilepsy is a chronic disorder of the nervous system characterized by recurrent seizures.
Inflammation is one of the six major causes of epilepsy, and its role in the pathogenesis of …

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

BD Semple, A Zamani, G Rayner, SR Shultz… - Neurobiology of …, 2019 - Elsevier
Survivors of traumatic brain injury (TBI) often develop chronic neurological, neurocognitive,
psychological, and psychosocial deficits that can have a profound impact on an individual's …

Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions

VM Golub, DS Reddy, C France - Pharmacological reviews, 2022 - Elsevier
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

Functional deficiency in endogenous interleukin‐1 receptor antagonist in patients with febrile infection‐related epilepsy syndrome

BDS Clarkson, RG LaFrance‐Corey… - Annals of …, 2019 - Wiley Online Library
Objective We recently reported successful treatment of a child with febrile infection‐related
epilepsy syndrome (FIRES), a subtype of new onset refractory status epilepticus, with the …

Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis

FP Mariajoseph, Z Chen, P Sekhar, SS Rewell… - …, 2022 - Wiley Online Library
Posttraumatic epilepsy (PTE) is a well‐known chronic complication following traumatic brain
injury (TBI). Despite some evidence that age at the time of injury may influence the likelihood …

Pharmacological targeting of brain inflammation in epilepsy: Therapeutic perspectives from experimental and clinical studies

T Ravizza, A Vezzani - Epilepsia open, 2018 - Wiley Online Library
Increasing evidence supports a pathogenic role of unabated neuroinflammation in various
central nervous system (CNS) diseases, including epilepsy. Neuroinflammation is not a …