The stiffness of living tissues and its implications for tissue engineering
The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …
Biomaterials to mimic and heal connective tissues
Connective tissue is one of the four major types of animal tissue and plays essential roles
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …
Mechanics of biological networks: from the cell cytoskeleton to connective tissue
From the cell cytoskeleton to connective tissues, fibrous networks are ubiquitous in
metazoan life as the key promoters of mechanical strength, support and integrity. In recent …
metazoan life as the key promoters of mechanical strength, support and integrity. In recent …
Viscoelasticity of tau proteins leads to strain rate-dependent breaking of microtubules during axonal stretch injury: predictions from a mathematical model
The unique viscoelastic nature of axons is thought to underlie selective vulnerability to
damage during traumatic brain injury. In particular, dynamic loading of axons has been …
damage during traumatic brain injury. In particular, dynamic loading of axons has been …
Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon
Despite the critical role tendons play in transmitting loads throughout the musculoskeletal
system, little is known about the microstructural mechanisms underlying their mechanical …
system, little is known about the microstructural mechanisms underlying their mechanical …
[HTML][HTML] The Achilles tendon: fundamental properties and mechanisms governing healing
BR Freedman, JA Gordon… - Muscles, ligaments and …, 2014 - ncbi.nlm.nih.gov
This review highlights recent research on Achilles tendon healing, and comments on the
current clinical controversy surrounding the diagnosis and treatment of injury. The processes …
current clinical controversy surrounding the diagnosis and treatment of injury. The processes …
Frequency domain updating of thin-walled workpiece dynamics using reduced order substructuring method in machining
The structural dynamics of thin-walled parts vary as the material is removed during
machining. This paper presents a new, computationally efficient reduced order dynamic …
machining. This paper presents a new, computationally efficient reduced order dynamic …
[HTML][HTML] The (dys) functional extracellular matrix
BR Freedman, ND Bade, CN Riggin, S Zhang… - … Et Biophysica Acta (BBA …, 2015 - Elsevier
The extracellular matrix (ECM) is a major component of the biomechanical environment with
which cells interact, and it plays important roles in both normal development and disease …
which cells interact, and it plays important roles in both normal development and disease …
Tendon exhibits complex poroelastic behavior at the nanoscale as revealed by high-frequency AFM-based rheology
Tendons transmit load from muscle to bone by utilizing their unique static and viscoelastic
tensile properties. These properties are highly dependent on the composition and structure …
tensile properties. These properties are highly dependent on the composition and structure …
Nonsurgical treatment and early return to activity leads to improved Achilles tendon fatigue mechanics and functional outcomes during early healing in an animal …
BR Freedman, JA Gordon, PR Bhatt… - Journal of …, 2016 - Wiley Online Library
Achilles tendon ruptures are common and devastating injuries; however, an optimized
treatment and rehabilitation protocol has yet to be defined. Therefore, the objective of this …
treatment and rehabilitation protocol has yet to be defined. Therefore, the objective of this …