Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
A Huyghe, A Trajkova, F Lavial - Trends in cell biology, 2024 - cell.com
The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …
Engineering considerations of iPSC-based personalized medicine
Personalized medicine aims to provide tailored medical treatment that considers the clinical,
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …
Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin
Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-
throughput, single-cell assessment of heterochromatin and its underlying genomic …
throughput, single-cell assessment of heterochromatin and its underlying genomic …
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
M Kovatcheva, E Melendez, D Chondronasiou… - Nature …, 2023 - nature.com
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …
H3K36 methylation maintains cell identity by regulating opposing lineage programmes
The epigenetic mechanisms that maintain differentiated cell states remain incompletely
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …
A fast chemical reprogramming system promotes cell identity transition through a diapause-like state
Cellular reprogramming by only small molecules holds enormous potentials for regenerative
medicine. However, chemical reprogramming remains a slow process and labour intensive …
medicine. However, chemical reprogramming remains a slow process and labour intensive …
Dissecting OCT4 defines the role of nucleosome binding in pluripotency
Pioneer transcription factors such as OCT4 can target silent genes embedded in
nucleosome-dense regions. How nucleosome interaction enables transcription factors to …
nucleosome-dense regions. How nucleosome interaction enables transcription factors to …
STARR-seq identifies active, chromatin-masked, and dormant enhancers in pluripotent mouse embryonic stem cells
Background Enhancers are distal regulators of gene expression that shape cell identity and
control cell fate transitions. In mouse embryonic stem cells (mESCs), the pluripotency …
control cell fate transitions. In mouse embryonic stem cells (mESCs), the pluripotency …
The emergence of Sox and POU transcription factors predates the origins of animal stem cells
Stem cells are a hallmark of animal multicellularity. Sox and POU transcription factors are
associated with stemness and were believed to be animal innovations, reported absent in …
associated with stemness and were believed to be animal innovations, reported absent in …
Nucleosome fibre topology guides transcription factor binding to enhancers
Cellular identity requires the concerted action of multiple transcription factors (TFs) bound
together to enhancers of cell-type-specific genes. Despite TFs recognizing specific DNA …
together to enhancers of cell-type-specific genes. Despite TFs recognizing specific DNA …