Why does the severity of COVID-19 differ with age?: understanding the mechanisms underlying the age gradient in outcome following SARS-CoV-2 infection
P Zimmermann, N Curtis - The Pediatric Infectious Disease …, 2022 - journals.lww.com
Although there are many hypotheses for the age-related difference in the severity of COVID-
19, differences in innate, adaptive and heterologous immunity, together with differences in …
19, differences in innate, adaptive and heterologous immunity, together with differences in …
Understanding why superspreading drives the COVID-19 pandemic but not the H1N1 pandemic
Two epidemiological parameters often characterise the transmissibility of infectious
diseases: the basic reproductive number (R0) and the dispersion parameter (k). R0 …
diseases: the basic reproductive number (R0) and the dispersion parameter (k). R0 …
IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study
M Shojaei, A Shamshirian, J Monkman, L Grice… - Frontiers in …, 2023 - frontiersin.org
Purpose Robust biomarkers that predict disease outcomes amongst COVID-19 patients are
necessary for both patient triage and resource prioritisation. Numerous candidate …
necessary for both patient triage and resource prioritisation. Numerous candidate …
Human models for COVID‐19 research
MNJ Woodall, T Masonou, KM Case… - The Journal of …, 2021 - Wiley Online Library
Currently, therapeutics for COVID‐19 are limited. To overcome this, it is important that we
use physiologically relevant models to reproduce the pathology of infection and evaluate the …
use physiologically relevant models to reproduce the pathology of infection and evaluate the …
Differences in saliva ACE2 activity among infected and non-infected adult and pediatric population exposed to SARS-CoV-2
D Jiménez, J Martínez-Sanz, T Sainz, C Calvo… - Journal of Infection, 2022 - Elsevier
Background Variations in the ACE2 activity in saliva could explain the striking differences of
susceptibility to infection and risk of severe disease. Methods We analyze the activity of …
susceptibility to infection and risk of severe disease. Methods We analyze the activity of …
Lessons learnt during the COVID‐19 pandemic: Why Australian schools should be prioritised to stay open
A Koirala, S Goldfeld, AC Bowen… - … of paediatrics and …, 2021 - Wiley Online Library
In 2020, school and early childhood educational centre (ECEC) closures affected over 1.5
billion school‐aged children globally as part of the COVID‐19 pandemic response …
billion school‐aged children globally as part of the COVID‐19 pandemic response …
[HTML][HTML] The impact of the COVID-19 pandemic on respiratory failure caused by respiratory viruses in children and adolescents
TB Gama, AA Ferraro, SE Vieira - Frontiers in Pediatrics, 2024 - frontiersin.org
Background In addition to the direct impact of the coronavirus disease 2019 (COVID-19)
pandemic on child/adolescent health, changes in infections caused by other viruses have …
pandemic on child/adolescent health, changes in infections caused by other viruses have …
[HTML][HTML] SARS-CoV-2 Infections in a Triad of Primary School Learners (Grades 1-7), Their Parents, and Teachers in KwaZulu-Natal, South Africa: Protocol for a Cross …
Background In low-and middle-income countries (LMICs) such as South Africa, there is
paucity of data on SARS-CoV-2 infections among children attending school, including …
paucity of data on SARS-CoV-2 infections among children attending school, including …
Comparison of SARS-CoV-2 evolution in paediatric primary airway epithelial cell cultures compared with vero-derived cell lines
SARS-CoV-2 can efficiently infect both children and adults, albeit with morbidity and
mortality positively associated with increasing host age and presence of co-morbidities …
mortality positively associated with increasing host age and presence of co-morbidities …
[HTML][HTML] Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting …
Viral infection induces production of type I interferons and expression of interferon-
stimulated genes (ISGs) that play key roles in inhibiting viral infection. Here, we show that …
stimulated genes (ISGs) that play key roles in inhibiting viral infection. Here, we show that …