The fibrogenic niche in kidney fibrosis: components and mechanisms
Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …
Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …
prevalence. Among several pathogenetic mechanisms responsible for disease progression …
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression
Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular
principles of kidney health and disease remain inadequately understood. We generated …
principles of kidney health and disease remain inadequately understood. We generated …
Signaling pathways of chronic kidney diseases, implications for therapeutics
Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …
Targeting TGF-β signal transduction for fibrosis and cancer therapy
D Peng, M Fu, M Wang, Y Wei, X Wei - Molecular cancer, 2022 - Springer
Transforming growth factor β (TGF-β) has long been identified with its intensive involvement
in early embryonic development and organogenesis, immune supervision, tissue repair, and …
in early embryonic development and organogenesis, immune supervision, tissue repair, and …
Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis
JH Wen, DY Li, S Liang, C Yang, JX Tang… - Frontiers in …, 2022 - frontiersin.org
As the essential regulators of organ fibrosis, macrophages undergo marked phenotypic and
functional changes after organ injury. These changes in macrophage phenotype and …
functional changes after organ injury. These changes in macrophage phenotype and …
Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment
S Huang, H Lu, J Chen, C Jiang, G Jiang… - Journal of Materials …, 2024 - pubs.rsc.org
Renal fibrosis is the result of all chronic kidney diseases and is becoming a major global
health hazard. Currently, traditional treatments for renal fibrosis are difficult to meet clinical …
health hazard. Currently, traditional treatments for renal fibrosis are difficult to meet clinical …
The role of JAK/STAT pathway in fibrotic diseases: molecular and cellular mechanisms
J Liu, F Wang, F Luo - Biomolecules, 2023 - mdpi.com
There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …
Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis
Following acute kidney injury (AKI), renal tubular cells may stimulate fibroblasts in a
paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation …
paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation …