1, 2, 3‐Triazole hybrids as anticancer agents: A review

MM Alam - Archiv der Pharmazie, 2022 - Wiley Online Library
Despite the advancements in the development of anticancer agents, more effective and
safer anticancer drugs still need to be developed as the current agents cause unwanted side …

Pentacyclic triterpenoids with nitrogen-containing heterocyclic moiety, privileged hybrids in anticancer drug discovery

V Khwaza, S Mlala, OO Oyedeji, BA Aderibigbe - Molecules, 2021 - mdpi.com
Pentacyclic triterpenoids are well-known phytochemicals with various biological activities
commonly found in plants as secondary metabolites. The wide range of biological activities …

Meldrum-Based-1H-1,2,3-Triazoles as Antidiabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition Activity, Molecular Docking Studies, and In Silico Approach

SK Avula, S Ullah, SA Halim, A Khan, MU Anwar… - ACS …, 2023 - ACS Publications
A series of novel alkyl derivatives (2–5a, b) and 1 H-1, 2, 3-triazole analogues (7a–k) of
Meldrum's acid were synthesized in a highly effective way by using “click” chemistry and …

Synthesis and antibiofilm activity of 1, 2, 3-triazole-pyridine hybrids against methicillin-resistant Staphylococcus aureus (MRSA)

T El Malah, HA Soliman, BA Hemdan… - New Journal of …, 2021 - pubs.rsc.org
Antibiotic-resistant bacteria are emerging at an alarming rate, posing a potential threat to
human health. We synthesised alkyne-functionalised pyridines 3 and 4via alkylation of …

An Atom-Economic Method for 1, 2, 3-Triazole Derivatives via Oxidative [3+ 2] Cycloaddition Harnessing the Power of Electrochemical Oxidation and Click Chemistry

M Bandyopadhyay, S Bhadra, S Pathak… - The Journal of …, 2023 - ACS Publications
An electrochemical method was developed to accomplish the reagentless synthesis of 4, 5-
disubstituted triazole derivatives employing secondary propargyl alcohol as C-3 synthon …

[PDF][PDF] Click synthesis, anticancer activity, and molecular docking investigation of some functional 1, 2, 3-triazole derivatives

M Hrimla, A Oubella, Y Laamari, L Bahsis… - Biointerface Res. Appl …, 2022 - roderic.uv.es
Abstract: 1, 2, 3-triazole skeleton is a privileged building block for the discovery of new
promising anticancer agents. In this report, new 1, 4-disubstituted 1, 2, 3-triazoles with the …

Triazole‐tethered boswellic acid derivatives against breast cancer: Synthesis, in vitro, and in‐silico studies

SK Avula, NU Rehman, F Khan, O Ullah… - Journal of Molecular …, 2023 - Elsevier
A series of new analogues of 3-O-acetyl-11-keto-β-boswellic acid (β-AKBA, 1), 3-O-acetyl-β-
boswellic acid (β-ABA, 2)(3–8) and 1H-1, 2, 3-triazole hybrids of β-AKBA (10a-j) were …

5-Amino-2-aryl-2H-1, 2, 3-triazole-4-carboxamides: Unique AIEE-gens and Selective Hg2+ Fluorosensors

NE Safronov, AS Minin, PA Slepukhin… - … Acta Part A: Molecular …, 2023 - Elsevier
A series of fluorescent sensors based on small molecule were designed and fully
characterised, demonstrating AIEE effect and revealing an outstanding ability to selectively …

Synthesis and antimicrobial activity of piperazine containing substituted 1, 2, 3-triazoles with amide linkage

P Yadav, CP Kaushik, A Kumar - Synthetic Communications, 2022 - Taylor & Francis
A series of Piperazine containing substituted 1, 2, 3-triazoles with amide linkage have been
designed and synthesized via click reaction between 1-aryl-4-(prop-2-yn-1-yl) piperazines …

Enlightening the sensing behaviour of click-derived 1, 2, 3-triazole for the selective detection of zirconium (iv) and its potential ability against Kelch-Neh2 via an in …

G Singh, S Khurana, H Kaur, B Rani… - New Journal of …, 2024 - pubs.rsc.org
Heavy metals pose significant health risks to both humans and animals, potentially leading
to severe exposure issues even when present in minimal amounts. There is a pressing need …