Toxicology and pharmacology of synthetic organoselenium compounds: An update

CW Nogueira, NV Barbosa, JBT Rocha - Archives of Toxicology, 2021‏ - Springer
Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

Recent advances in tandem selenocyclization and tellurocyclization with alkenes and alkynes

K Sun, X Wang, C Li, H Wang, L Li - Organic Chemistry Frontiers, 2020‏ - pubs.rsc.org
Seleno-containing heterocycles exist widely in pharmaceutical molecules and the skeletons
of natural products. The addition of organoselenium to alkenes and alkynes via …

Design of diselenide-bridged hyaluronic acid nano-antioxidant for efficient ROS scavenging to relieve colitis

J Xu, T Chu, T Yu, N Li, C Wang, C Li, Y Zhang… - Acs Nano, 2022‏ - ACS Publications
Overproduction of reactive oxygen species (ROS), a key characteristic of inflammatory bowel
disease (IBD), is responsible for dysregulation of signal transduction, inflammatory …

Organoselenium and organotellurium compounds: toxicology and pharmacology

CW Nogueira, G Zeni, JBT Rocha - Chemical reviews, 2004‏ - ACS Publications
Organoselenium compounds have found such wide utility because of their effects on an
extraordinary number of very different reactions, including many carbon-carbon bond …

Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds

CW Nogueira, JBT Rocha - Archives of toxicology, 2011‏ - Springer
The advance in the area of synthesis and reactivity of organoselenium, as well as the
discovery that selenium was the cause of severe intoxication episodes of livestock in the …

Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies

M Farina, JBT Rocha, M Aschner - Life sciences, 2011‏ - Elsevier
Neurological disorders are common, costly, and can cause enduring disability. Although
mostly unknown, a few environmental toxicants are recognized causes of neurological …

Synthesis of Seleno‐Heterocycles via Electrophilic/Radical Cyclization of Alkyne Containing Heteroatoms

AD Sonawane, RA Sonawane… - Advanced Synthesis …, 2020‏ - Wiley Online Library
Abstract containing heterocyclic scaffolds by virtue of their interesting reactivities and a
broad range of applications in the medicinal and materials chemistry. This review involves …

Oxidative stress in MeHg-induced neurotoxicity

M Farina, M Aschner, JBT Rocha - Toxicology and applied pharmacology, 2011‏ - Elsevier
Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological
and developmental deficits in animals and humans. Although the molecular mechanisms …

Organoselenium compounds as mimics of selenoproteins and thiol modifier agents

NV Barbosa, CW Nogueira, PA Nogara… - Metallomics, 2017‏ - academic.oup.com
Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

A Solvent- and Metal-Free Synthesis of 3-Chacogenyl-indoles Employing DMSO/I2 as an Eco-friendly Catalytic Oxidation System

JB Azeredo, M Godoi, GM Martins… - The Journal of …, 2014‏ - ACS Publications
Herein, we describe a solvent-and metal-free method for the synthesis of 3-chalcogenyl-
indoles from indoles and diorganyl dichalcogenides using an equivalent amount of DMSO …