DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic
integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

Fast and selective isolation of single cells with unique spatial and morphological traits
remains a technical challenge. Here, we address this by establishing high-speed image …

Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-
strand breaks by homologous recombination and consequently are hypersensitive to DNA …

The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a
threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of …

The DNA damage response factor 53BP1 functions at the intersection of two major double
strand break (DSB) repair pathways–promoting nonhomologous end-joining (NHEJ) and …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Chromatin structure has a crucial role in processes of metabolism, including transcription,
DNA replication and DNA damage repair. An evolutionarily conserved variant of histone …

The DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive
resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as …

Transcriptional regulation at the level of elongation is vital for the control of gene expression
and metazoan development. The mixed lineage leukemia (MLL) protein and its Drosophila …