3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs
Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …
alternatives for initial drug screening to increase drug development efficiency. In addition to …
Advanced cell culture techniques for cancer drug discovery
Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained
The potential of a spheroid tumor model composed of cells in different proliferative and
metabolic states for the development of new anticancer strategies has been amply …
metabolic states for the development of new anticancer strategies has been amply …
A systematic strategy of combinational blow for overcoming cascade drug resistance via NIR‐light‐triggered hyperthermia
L Wang, Y Yu, D Wei, L Zhang, X Zhang… - Advanced …, 2021 - Wiley Online Library
A systematic combination strategy is proposed for overcoming cisplatin resistance using
near‐infrared (NIR)‐light‐triggered hyperthermia. A new photothermal polymer DAP‐F is …
near‐infrared (NIR)‐light‐triggered hyperthermia. A new photothermal polymer DAP‐F is …
Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery
K Stock, MF Estrada, S Vidic, K Gjerde, A Rudisch… - Scientific reports, 2016 - nature.com
Abstract Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three
dimensional (3D) architecture and complexity of human tumors. More representative models …
dimensional (3D) architecture and complexity of human tumors. More representative models …
Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications
MC Decarli, R Amaral, DP Dos Santos, LB Tofani… - …, 2021 - iopscience.iop.org
Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
High-content monitoring of drug effects in a 3D spheroid model
A recent decline in the discovery of novel medications challenges the widespread use of 2D
monolayer cell assays in the drug discovery process. As a result, the need for more …
monolayer cell assays in the drug discovery process. As a result, the need for more …
Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations
J Jabs, FM Zickgraf, J Park, S Wagner… - Molecular systems …, 2017 - embopress.org
Cancer drug screening in patient‐derived cells holds great promise for personalized
oncology and drug discovery but lacks standardization. Whether cells are cultured as …
oncology and drug discovery but lacks standardization. Whether cells are cultured as …
Anticancer drug discovery using multicellular tumor spheroid models
Introduction: Despite the increasing financial outlay on cancer research and drug discovery,
many advanced cancers remain incurable. One possible strategy for increasing the approval …
many advanced cancers remain incurable. One possible strategy for increasing the approval …
Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates …
Despite untiring efforts to develop therapies for pancreatic ductal adenocarcinoma (PDAC),
survival statistics remain dismal, necessitating distinct approaches. Photodynamic priming …
survival statistics remain dismal, necessitating distinct approaches. Photodynamic priming …