Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signal
transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine …

Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous
candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have …

Heterozygous gain-of-function (GOF) mutations in STAT1 in patients with chronic
mucocutaneous candidiasis (CMC) and hypothyroidism were discovered in 2011. CMC is …

Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent
infections affecting the nails, skin and oral and genital mucosae caused by Candida spp …

Background Gain-of-function (GOF) mutations in the human signal transducer and activator
of transcription 1 (STAT1) manifest in immunodeficiency and autoimmunity with impaired TH …

Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent
infections of the skin, nail, oral, and genital mucosae with Candida species, mainly C …

Chronic mucocutaneous candidiasis (CMC) is defined as recurrent or persistent infection of
the skin, nails, and/or mucosae with commensal Candida species. The first genetic etiology …

Background Gain-of-function (GOF) mutations in signal transducer and activator of
transcription 1 (STAT1) cause susceptibility to a range of infections, autoimmunity, immune …

To the Editor: Recently, **ng et al 1 demonstrated the role of cytotoxic T lymphocytes in
alopecia areata (AA) and provided important mechanistic information on the pathogenic T …