The neurobiology of activational aspects of motivation: exertion of effort, effort-based decision making, and the role of dopamine
Motivational processes are complex and multifaceted, with both directional and activational
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Motivation has been defined as the process that allows organisms to regulate their internal
and external environment, and control the probability, proximity and availability of stimuli. As …
and external environment, and control the probability, proximity and availability of stimuli. As …
Making sense of rodent models of anhedonia
A markedly reduced interest or pleasure in activities previously considered pleasurable is a
main symptom in mood disorder and psychosis and is often present in other psychiatric …
main symptom in mood disorder and psychosis and is often present in other psychiatric …
Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment.
One of the most debilitating aspects of schizophrenia is an apparent interest in or ability to
exert effort for rewards. Such “negative symptoms” may prevent individuals from obtaining …
exert effort for rewards. Such “negative symptoms” may prevent individuals from obtaining …
Mesolimbic dopamine and the regulation of motivated behavior
It has been known for some time that nucleus accumbens dopamine (DA) is involved in
aspects of motivation, but theoretical approaches to understanding the functions of DA have …
aspects of motivation, but theoretical approaches to understanding the functions of DA have …
Anhedonia in depression: biological mechanisms and computational models
Highlights•Discrete processes underlying anhedonia can be computationally
operationalized.•Approaches include models of reinforcement learning and effort-based …
operationalized.•Approaches include models of reinforcement learning and effort-based …
Dopamine, effort-based choice, and behavioral economics: basic and translational research
Operant behavior is not only regulated by factors related to the quality or quantity of
reinforcement, but also by the work requirements inherent in performing instrumental …
reinforcement, but also by the work requirements inherent in performing instrumental …
Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus
Cannabinoid derivatives have shown promising results for treating neuropsychiatric
disorders, including drug addiction. Recent studies on the therapeutic effects of Cannabidiol …
disorders, including drug addiction. Recent studies on the therapeutic effects of Cannabidiol …
Amotivation in schizophrenia: integrated assessment with behavioral, clinical, and imaging measures
Motivational deficits play a central role in disability caused by schizophrenia and constitute a
major unmet therapeutic need. Negative symptoms have previously been linked to …
major unmet therapeutic need. Negative symptoms have previously been linked to …
[HTML][HTML] Caffeine and selective adenosine receptor antagonists as new therapeutic tools for the motivational symptoms of depression
Major depressive disorder is one of the most common and debilitating psychiatric disorders.
Some of the motivational symptoms of depression, such anergia (lack of self-reported …
Some of the motivational symptoms of depression, such anergia (lack of self-reported …