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Mechanism of action of ribosomally synthesized and post-translationally modified peptides
C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …
product class that has undergone significant expansion due to the rapid growth in genome …
Molecular machines that facilitate bacterial outer membrane protein biogenesis
Almost all outer membrane proteins (OMPs) in Gram-negative bacteria contain a β-barrel
domain that spans the outer membrane (OM). To reach the OM, OMPs must be translocated …
domain that spans the outer membrane (OM). To reach the OM, OMPs must be translocated …
The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase
Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the
antimicrobial resistance crisis,–. Gram-negative bacteria are protected by an additional outer …
antimicrobial resistance crisis,–. Gram-negative bacteria are protected by an additional outer …
Structural basis of BAM-mediated outer membrane β-barrel protein assembly
C Shen, S Chang, Q Luo, KC Chan, Z Zhang, B Luo… - Nature, 2023 - nature.com
The outer membrane structure is common in Gram-negative bacteria, mitochondria and
chloroplasts, and contains outer membrane β-barrel proteins (OMPs) that are essential …
chloroplasts, and contains outer membrane β-barrel proteins (OMPs) that are essential …
Outer membrane protein assembly mediated by BAM-SurA complexes
The outer membrane is a formidable barrier that protects Gram-negative bacteria against
environmental threats. Its integrity requires the correct folding and insertion of outer …
environmental threats. Its integrity requires the correct folding and insertion of outer …
Peptidoglycan maturation controls outer membrane protein assembly
Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan
layer are crucial for the maintenance of cellular integrity and enable survival in challenging …
layer are crucial for the maintenance of cellular integrity and enable survival in challenging …
Surveying membrane landscapes: a new look at the bacterial cell surface
Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …
[HTML][HTML] Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria
β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …
Outer membrane biogenesis
A Konovalova, DE Kahne… - Annual review of …, 2017 - annualreviews.org
The hallmark of gram-negative bacteria and organelles such as mitochondria and
chloroplasts is the presence of an outer membrane. In bacteria such as Escherichia coli, the …
chloroplasts is the presence of an outer membrane. In bacteria such as Escherichia coli, the …
Structure of a nascent membrane protein as it folds on the BAM complex
Mitochondria, chloroplasts and Gram-negative bacteria are encased in a double layer of
membranes. The outer membrane contains proteins with a β-barrel structure,. β-Barrels are …
membranes. The outer membrane contains proteins with a β-barrel structure,. β-Barrels are …