Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Molecular machines that facilitate bacterial outer membrane protein biogenesis

MT Doyle, HD Bernstein - Annual Review of Biochemistry, 2024 - annualreviews.org
Almost all outer membrane proteins (OMPs) in Gram-negative bacteria contain a β-barrel
domain that spans the outer membrane (OM). To reach the OM, OMPs must be translocated …

The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase

H Kaur, RP Jakob, JK Marzinek, R Green, Y Imai… - Nature, 2021 - nature.com
Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the
antimicrobial resistance crisis,–. Gram-negative bacteria are protected by an additional outer …

Structural basis of BAM-mediated outer membrane β-barrel protein assembly

C Shen, S Chang, Q Luo, KC Chan, Z Zhang, B Luo… - Nature, 2023 - nature.com
The outer membrane structure is common in Gram-negative bacteria, mitochondria and
chloroplasts, and contains outer membrane β-barrel proteins (OMPs) that are essential …

Outer membrane protein assembly mediated by BAM-SurA complexes

KL Fenn, JE Horne, JA Crossley, N Böhringer… - Nature …, 2024 - nature.com
The outer membrane is a formidable barrier that protects Gram-negative bacteria against
environmental threats. Its integrity requires the correct folding and insertion of outer …

Peptidoglycan maturation controls outer membrane protein assembly

G Mamou, F Corona, R Cohen-Khait, NG Housden… - Nature, 2022 - nature.com
Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan
layer are crucial for the maintenance of cellular integrity and enable survival in challenging …

Surveying membrane landscapes: a new look at the bacterial cell surface

T Lithgow, CJ Stubenrauch, MPH Stumpf - Nature Reviews Microbiology, 2023 - nature.com
Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …

[HTML][HTML] Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria

JE Horne, DJ Brockwell, SE Radford - Journal of Biological Chemistry, 2020 - Elsevier
β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

Outer membrane biogenesis

A Konovalova, DE Kahne… - Annual review of …, 2017 - annualreviews.org
The hallmark of gram-negative bacteria and organelles such as mitochondria and
chloroplasts is the presence of an outer membrane. In bacteria such as Escherichia coli, the …

Structure of a nascent membrane protein as it folds on the BAM complex

D Tomasek, S Rawson, J Lee, JS Wzorek, SC Harrison… - Nature, 2020 - nature.com
Mitochondria, chloroplasts and Gram-negative bacteria are encased in a double layer of
membranes. The outer membrane contains proteins with a β-barrel structure,. β-Barrels are …