Opioid use disorder and the brain: a clinical perspective

K Herlinger, A Lingford‐Hughes - Addiction, 2022‏ - Wiley Online Library
Opioid use disorder (OUD) has gained increasing publicity and interest during recent years,
with many countries describing problems of epidemic proportions with regard to opioid use …

Chronic heroin use disorder and the brain: Current evidence and future implications

S Tolomeo, JD Steele, H Ekhtiari… - Progress in Neuro …, 2021‏ - Elsevier
The incidence of chronic heroin use disorder, including overdose deaths, has reached
epidemic proportions. Here we summarise and evaluate our knowledge of the relationship …

Multimodal frontal neuroimaging markers predict longitudinal craving reduction in abstinent individuals with heroin use disorder

X Wen, W Yang, Z Du, J Zhao, Y Li, D Yu… - Journal of Psychiatric …, 2024‏ - Elsevier
The variation in improvement among individuals with addiction after abstinence is a critical
issue. Here, we aimed to identify robust multimodal markers associated with high response …

Forging neuroimaging targets for recovery in opioid use disorder

JL Stewart, AC May, RL Aupperle, J Bodurka - Frontiers in psychiatry, 2019‏ - frontiersin.org
The United States is in the midst of an opioid epidemic and lacks a range of successful
interventions to reduce this public health burden. Many individuals with opioid use disorder …

Compulsivity and inhibitory control deficits in abstinent individuals with heroin addiction and their biological siblings compared with unrelated healthy control …

WS Yan, SJ Liu, DH Zheng - Biological Psychiatry: Cognitive Neuroscience …, 2024‏ - Elsevier
Background Compulsivity represents the performance of persistent and repetitive acts
despite negative consequences and is considered one of the critical mechanisms for drug …

Blunted expected reward value signals in binge alcohol drinkers

S Tolomeo, A Baldacchino, JD Steele - Journal of Neuroscience, 2023‏ - jneurosci.org
Alcohol-related morbidities and mortality are highly prevalent, increasing the burden to
societies and health systems with 3 million deaths globally each year in young adults …

Exploring decision-making performance in young adults with mental health disorders: a comparative study using the Cambridge gambling task

R Effah, K Ioannidis, JE Grant… - Psychological …, 2024‏ - cambridge.org
Decision-making deficits, assessed cognitively, are often associated with mental health
symptoms, however, this relationship is not fully understood. This paper explores the …

Protracted abstinence in males with an opioid use disorder: partial recovery of nucleus accumbens function

S Tolomeo, A Baldacchino, ND Volkow… - Translational …, 2022‏ - nature.com
Opioid use disorder (OUD) affects more than 27 million people globally accounting for more
than 300,000 deaths annually. Protracted abstinence among individuals with OUD is rare …

Compulsivity and impulsivity in opioid dependence

S Tolomeo, F Davey, JD Steele… - Drug and Alcohol …, 2021‏ - Elsevier
Objective Chronic exposure to illicit opioid drugs can cause serious health and social
problems. However, less is known about the differential effect of various opioid treatments …

[HTML][HTML] The molecular neurobiology and neuropathology of opioid use disorder

CA Blackwood, JL Cadet - Current research in neurobiology, 2021‏ - Elsevier
The number of people diagnosed with opioid use disorder has skyrocketed as a
consequence of the opioid epidemic and the increased prescribing of opioid drugs for …