Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation

J Zhang, R Cruz-Cosme, C Zhang, D Liu, Q Tang… - Mbio, 2024 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital
role in viral pathogenesis and coronavirus disease 2019 (COVID-19). Like the spike protein …

Insights into the Activation of Unfolded Protein Response Mechanism during Coronavirus Infection

P Keramidas, M Pitou, E Papachristou… - Current Issues in …, 2024 - mdpi.com
Coronaviruses represent a significant class of viruses that affect both animals and humans.
Their replication cycle is strongly associated with the endoplasmic reticulum (ER), which …

Transcriptional Profiling of SARS-CoV-2-Infected Calu-3 Cells Reveals Immune-Related Signaling Pathways

EPV Pereira, SM da Silva Felipe, RM de Freitas… - Pathogens, 2023 - mdpi.com
The COVID-19 disease, caused by the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2), emerged in late 2019 and rapidly spread worldwide, becoming a pandemic …