IL-6 in inflammation, autoimmunity and cancer

T Hirano - International immunology, 2021 - academic.oup.com
IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Cytokines in inflammatory disease

S Kany, JT Vollrath, B Relja - International journal of molecular sciences, 2019 - mdpi.com
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …

Macrophage cytokines: involvement in immunity and infectious diseases

G Arango Duque, A Descoteaux - Frontiers in immunology, 2014 - frontiersin.org
The evolution of macrophages has made them primordial for both development and
immunity. Their functions range from the sha** of body plans to the ingestion and …

IL-6 as a keystone cytokine in health and disease

CA Hunter, SA Jones - Nature immunology, 2015 - nature.com
Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

Neutrophil recruitment and function in health and inflammation

E Kolaczkowska, P Kubes - Nature reviews immunology, 2013 - nature.com
Neutrophils have traditionally been thought of as simple foot soldiers of the innate immune
system with a restricted set of pro-inflammatory functions. More recently, it has become …

An emerging role for neutrophil extracellular traps in noninfectious disease

SK Jorch, P Kubes - Nature medicine, 2017 - nature.com
The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils
to help catch and kill bacteria. However, increasing evidence suggests that this process …

[HTML][HTML] The pro-and anti-inflammatory properties of the cytokine interleukin-6

J Scheller, A Chalaris, D Schmidt-Arras… - Biochimica et Biophysica …, 2011 - Elsevier
Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also
in the regulation of metabolic, regenerative, and neural processes. In classic signaling …

Interleukin 6 as an energy allocator in muscle tissue

TM Kistner, BK Pedersen, DE Lieberman - Nature metabolism, 2022 - nature.com
Extensive research has shown that interleukin 6 (IL-6) is a multifunctional molecule that is
both proinflammatory and anti-inflammatory, depending on the context. Here, we combine …

Inflammation, fracture and bone repair

F Loi, LA Córdova, J Pajarinen, T Lin, Z Yao… - Bone, 2016 - Elsevier
The reconstitution of lost bone is a subject that is germane to many orthopedic conditions
including fractures and non-unions, infection, inflammatory arthritis, osteoporosis …

[HTML][HTML] Muscle as an endocrine organ: focus on muscle-derived interleukin-6

BK Pedersen, MA Febbraio - Physiological reviews, 2008 - journals.physiology.org
Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been
suggested that cytokines and other peptides that are produced, expressed, and released by …