As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS),
there is an unmet need for treatments that slow neurodegeneration resulting from secondary …

Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …

Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction
characterized by premature exhaustion of primordial follicles. POI causes infertility, severe …

Cancer cells and ischemic diseases exhibit unique metabolic responses and adaptations to
energy stress. Forkhead box O 3a (FoxO3a) is a transcription factor that plays an important …

Ischemia-reperfusion (I/R) injury is a major challenge in perioperative medicine that
contributes to pathological damage in various conditions, including ischemic stroke …

Ferroptosis is a regulated cell death that characterizes the lethal lipid peroxidation and iron
overload, which may contribute to early brain injury (EBI) pathogenesis after subarachnoid …

Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …

Ischemia/reperfusion injury (IRI) is prone to occur after kidney transplantation, leading to
delayed graft function (DGF). MicroRNAs play a crucial role in the pathogenesis of …