The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …

Amphisomes are intermediate/hybrid organelles produced through the fusion of endosomes
with autophagosomes within cells. Amphisome formation is an essential step during a …

Lysosomes serve as degradation hubs for the turnover of endocytic and autophagic cargos,
which is essential for neuron function and survival. Deficits in lysosome function result in …

Neurons are the largest known cells, with complex and highly polarized morphologies. As
such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

The neurotrophic tropomyosin receptor kinase (NTRK) genes (NTRK1, NTRK2, and NTRK3)
code for three transmembrane high-affinity tyrosine-kinase receptors for nerve growth factors …

Melatonin, N-acetyl-5-hydroxytryptamine, is a hormone that synchronizes the internal
environment with the photoperiod. It is synthesized in the pineal gland and greatly depends …

In neurons, long-distance communication between axon terminals and cell bodies is a
critical determinant in establishing and maintaining neural circuits. Neurotrophins are …

Most mammalian neurons have a narrow axon, which constrains the passage of large
cargoes such as autophagosomes that can be larger than the axon diameter. Radial axonal …

To overcome the limitations of the clinical use of neurotrophins nerve growth factor (NGF)
and brain‐derived neurotrophic factor (BDNF), scientists have been trying to create their low …