Establishing biomarkers for soft tissue sarcomas
AM Czarnecka, P Chmiel, P Błoński… - Expert Review of …, 2024 - Taylor & Francis
Introduction Soft tissue sarcomas (STS) are a rare and diverse group of tumors. Curative
options are limited to localized disease, with surgery being the mainstay. Advanced stages …
options are limited to localized disease, with surgery being the mainstay. Advanced stages …
Genetic, epigenetic and transcriptome alterations in liposarcoma for target therapy selection
Simple Summary Liposarcoma is the most widespread soft-tissue sarcoma in adults. This
review summarizes the molecular genetics and epigenetics of the main liposarcoma …
review summarizes the molecular genetics and epigenetics of the main liposarcoma …
Safety and efficacy of percutaneous cryoablation for recurrent or metastatic soft-tissue sarcoma in adult patients
BACKGROUND. Treatment options are limited in patients with recurrent or metastatic
disease after initial treatment of soft-tissue sarcoma (STS) by surgical resection, radiation, or …
disease after initial treatment of soft-tissue sarcoma (STS) by surgical resection, radiation, or …
Safety and efficacy of percutaneous image‐guided ablation for soft tissue sarcoma metastases to the liver
Purpose To evaluate outcomes following percutaneous image‐guided ablation of soft tissue
sarcoma metastases to the liver. Materials and Methods A single‐institution retrospective …
sarcoma metastases to the liver. Materials and Methods A single‐institution retrospective …
Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes
Purpose: Chondrosarcomas are the most common primary bone tumor in adults. Isocitrate
dehydrogenase 1 (IDH1) and IDH2 mutations are prevalent. We aimed to assess the clinico …
dehydrogenase 1 (IDH1) and IDH2 mutations are prevalent. We aimed to assess the clinico …
[HTML][HTML] Circulating tumor DNA in clinical trials for solid tumors: Challenges and current applications
Tumor derived biomarkers including circulating tumor DNA (ctDNA) and/or circulating
tumors cells (CTCs) may be detected and quantified through liquid biopsy (LB). ctDNA …
tumors cells (CTCs) may be detected and quantified through liquid biopsy (LB). ctDNA …
The role of systemic therapy in advanced skull base chordomas: overview of the current state and the MD Anderson protocol
The role of systemic therapy in primary or advanced and metastatic chordoma has been
traditionally limited because of the inherent resistance to cytotoxic therapies and lack of …
traditionally limited because of the inherent resistance to cytotoxic therapies and lack of …
TRKing sarcomas for precision medicine: Seek, and ye shall find!
Plain language summary The way in which we treat different types of cancer has changed a
lot because of genome‐driven precision oncology. This approach uses information from a …
lot because of genome‐driven precision oncology. This approach uses information from a …
Reclassification of a spindle cell sarcoma after identification of a TFG‐ROS1 fusion: A case demonstrating the clinical benefit of next‐generation sequencing in …
JJ Lim, EY Chen, SK Schaub… - Molecular Genetics & …, 2024 - Wiley Online Library
Abstract Background Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal soft
tissue sarcomas that often present diagnostic challenges due to their wide and varied …
tissue sarcomas that often present diagnostic challenges due to their wide and varied …
Machine learning-based analysis of genomic and transcriptomic data unveils sarcoma clusters with superlative prognostic and predictive value
M Esperanca-Martins, H Vasques, MS Ravasqueira… - medRxiv, 2025 - medrxiv.org
Soft tissue sarcomas (STS) histopathological classification system has several conceptual
caveats, impacting prognostication and treatment. The clinical and molecular–based tools …
caveats, impacting prognostication and treatment. The clinical and molecular–based tools …