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Glucose-6-Phosphate dehydrogenase, redox homeostasis and embryogenesis
PH Chen, WY Tjong, HC Yang, HY Liu, A Stern… - International Journal of …, 2022 - mdpi.com
Normal embryogenesis requires complex regulation and precision, which depends on
multiple mechanistic details. Defective embryogenesis can occur by various mechanisms …
multiple mechanistic details. Defective embryogenesis can occur by various mechanisms …
Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution
Viruses in built environments (BEs) raise public health concerns, yet they are generally less
studied than bacteria. To better understand viral dynamics in BEs, this study assesses …
studied than bacteria. To better understand viral dynamics in BEs, this study assesses …
Advantages of the outgrowth model for evaluating the implantation competence of blastocysts
J Kim, J Lee, JH Jun - Clinical and experimental reproductive …, 2020 - pmc.ncbi.nlm.nih.gov
The implantation process is highly complex and difficult to mimic in vitro, and a reliable
experimental model of implantation has yet to be established. Many researchers have used …
experimental model of implantation has yet to be established. Many researchers have used …
junctionCounts: comprehensive alternative splicing analysis and prediction of isoform-level impacts to the coding sequence
AJ Ritter, A Wallace, N Ronaghi… - NAR Genomics and …, 2024 - academic.oup.com
Alternative splicing (AS) is emerging as an important regulatory process for complex
biological processes. Transcriptomic studies therefore commonly involve the identification …
biological processes. Transcriptomic studies therefore commonly involve the identification …
Discovery of two new isoforms of the human DUT gene
In human cells two dUTPase isoforms have been described: one nuclear (DUT-N) and one
mitochondrial (DUT-M), with cognate localization signals. In contrast, here we identified two …
mitochondrial (DUT-M), with cognate localization signals. In contrast, here we identified two …
Characterization of dUTPase expression in mouse postnatal development and adult neurogenesis
The enzyme dUTPase has an essential role in maintaining genomic integrity. In mouse,
nuclear and mitochondrial isoforms of the enzyme have been described. Here we present …
nuclear and mitochondrial isoforms of the enzyme have been described. Here we present …
Full-length inhibitor protein is the most effective to perturb human dUTPase activity
It has been demonstrated recently that knockout of the dUTPase enzyme leads to early
embryonic lethality in mice. However, to explore the physiological processes arising upon …
embryonic lethality in mice. However, to explore the physiological processes arising upon …
[HTML][HTML] Viral dUTPases: modulators of innate immunity
Most free-living organisms encode for a deoxyuridine triphosphate nucleotidohydrolase
(dUTPase; EC 3.6. 1.23). dUTPases represent a family of metalloenzymes that catalyze the …
(dUTPase; EC 3.6. 1.23). dUTPases represent a family of metalloenzymes that catalyze the …
Exploration of the Effect on Genome-Wide DNA Methylation by miR-143 Knock-Out in Mice Liver
MiR-143 play an important role in hepatocellular carcinoma and liver fibrosis via inhibiting
hepatoma cell proliferation. DNA methyltransferase 3 alpha (DNMT3a), as a target of miR …
hepatoma cell proliferation. DNA methyltransferase 3 alpha (DNMT3a), as a target of miR …
Bacteriophage T5 dUTPase: Combination of Common Enzymatic and Novel Functions
The main function of dUTPases is to regulate the cellular levels of dUTP and dTTP, thereby
playing a crucial role in DNA repair mechanisms. Despite the fact that mutant organisms with …
playing a crucial role in DNA repair mechanisms. Despite the fact that mutant organisms with …