[HTML][HTML] Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications

S Ijaz, J Iqbal, BA Abbasi, Z Ullah, T Yaseen… - Biomedicine & …, 2023 - Elsevier
Cancer is still the leading cause of death worldwide, burdening the global medical system.
Rosmarinic acid (RA) is among the first secondary metabolites discovered and it is a …

Effect of antioxidants supplementation on aging and longevity

I Sadowska-Bartosz, G Bartosz - BioMed research international, 2014 - Wiley Online Library
If aging is due to or contributed by free radical reactions, as postulated by the free radical
theory of aging, lifespan of organisms should be extended by administration of exogenous …

Antiaging agents: Safe interventions to slow aging and healthy life span extension

JK Liu - Natural Products and Bioprospecting, 2022 - Springer
Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

Hormesis determines lifespan

EJ Calabrese, M Nascarella, P Pressman… - Ageing Research …, 2024 - Elsevier
This paper addresses how long lifespan can be extended via multiple interventions, such as
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …

Effects of rosmarinic acid on nervous system disorders: an updated review

M Ghasemzadeh Rahbardar… - … Archives of Pharmacology, 2020 - Springer
Nowadays, the worldwide interest is growing to use medicinal plants and their active
constituents to develop new potent medicines with fewer side effects. Precise dietary …

Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

G Brunetti, G Di Rosa, M Scuto, M Leri… - International journal of …, 2020 - mdpi.com
Numerous studies highlighted the beneficial effects of the Mediterranean diet (MD) in
maintaining health, especially during ageing. Even neurodegeneration, which is part of the …

Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models

G Di Rosa, G Brunetti, M Scuto… - International Journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is the second most prevalent late-age onset neurodegenerative
disorder, affecting 1% of the population after the age of about 60 years old and 4% of those …

A simple and a reliable method to quantify antioxidant activity in vivo

MP de Torre, RY Cavero, MI Calvo, JL Vizmanos - Antioxidants, 2019 - mdpi.com
The characterization of compounds with antioxidant activity is of great interest due to their
ability to reduce reactive oxygen species production and, therefore, prevent some age …

Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans

NO Okoro, AS Odiba, PO Osadebe, EO Omeje, G Liao… - Molecules, 2021 - mdpi.com
In the forms of either herbs or functional foods, plants and their products have attracted
medicinal, culinary, and nutraceutical applications due to their abundance in bioactive …

Biphasic dose-response induced by phytochemicals: experimental evidence

J Jodynis-Liebert, M Kujawska - Journal of Clinical Medicine, 2020 - mdpi.com
Many phytochemicals demonstrate nonmonotonic dose/concentration-response termed
biphasic dose-response and are considered to be hormetic compounds, ie, they induce …