Targeting mechanisms of tailed bacteriophages

FL Nobrega, M Vlot, PA De Jonge… - Nature Reviews …, 2018 - nature.com
Phages differ substantially in the bacterial hosts that they infect. Their host range is
determined by the specific structures that they use to target bacterial cells. Tailed phages …

Killing in the name of: T6SS structure and effector diversity

LP Allsopp, P Bernal - Microbiology, 2023 - microbiologyresearch.org
The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to
optimize their environment, including deploying the type VI secretion system (T6SS). Acting …

Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition

F Navarro-Garcia, F Ruiz-Perez, Á Cataldi… - Frontiers in …, 2019 - frontiersin.org
Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage
tissue sites, and evade the immune system. One essential strategy of Gram-negative …

Assembly and subcellular localization of bacterial type VI secretion systems

J Wang, M Brodmann, M Basler - Annual review of microbiology, 2019 - annualreviews.org
Bacteria need to deliver large molecules out of the cytosol to the extracellular space or even
across membranes of neighboring cells to influence their environment, prevent predation …

Polymorphic toxins and their immunity proteins: diversity, evolution, and mechanisms of delivery

ZC Ruhe, DA Low, CS Hayes - Annual review of microbiology, 2020 - annualreviews.org
All bacteria must compete for growth niches and other limited environmental resources.
These existential battles are waged at several levels, but one common strategy entails the …

Acinetobacter baumannii: Envelope Determinants That Control Drug Resistance, Virulence, and Surface Variability

E Geisinger, W Huo, J Hernandez-Bird… - Annual review of …, 2019 - annualreviews.org
Acinetobacter baumannii has emerged as an important nosocomial pathogen, particularly
for patients in intensive care units and with invasive indwelling devices. The most recent …

In situ architecture, function, and evolution of a contractile injection system

D Böck, JM Medeiros, HF Tsao, T Penz, GL Weiss… - Science, 2017 - science.org
Contractile injection systems mediate bacterial cell-cell interactions by a bacteriophage tail–
like structure. In contrast to extracellular systems, the type 6 secretion system (T6SS) is …

[HTML][HTML] Advances in cryo-electron tomography and subtomogram averaging and classification

P Zhang - Current opinion in structural biology, 2019 - Elsevier
Highlights•Cryo-electron tomography (cryoET) subtomogram averaging has emerged as a
structural biology method for sparse and heterogenerous sampls.•CryoET subtomogram …

Structure of a bacterial Rhs effector exported by the type VI secretion system

P Günther, D Quentin, S Ahmad, K Sachar… - PLoS …, 2022 - journals.plos.org
The t ype VI s ecretion s ystem (T6SS) is a widespread protein export apparatus found in
Gram-negative bacteria. The majority of T6SSs deliver toxic effector proteins into competitor …

Mechanism of loading and translocation of type VI secretion system effector Tse6

D Quentin, S Ahmad, P Shanthamoorthy… - Nature …, 2018 - nature.com
The type VI secretion system (T6SS) primarily functions to mediate antagonistic interactions
between contacting bacterial cells, but also mediates interactions with eukaryotic hosts. This …