Regulation of GPCR activity, trafficking and localization by GPCR‐interacting proteins
GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets
Because G-protein coupled receptors (GPCRs) continue to represent excellent targets for
the discovery and development of small-molecule therapeutics, it is posited that additional …
the discovery and development of small-molecule therapeutics, it is posited that additional …
Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice
Brown adipocytes dissipate energy, whereas white adipocytes are an energy storage site.
We explored the plasticity of different white adipose tissue depots in acquiring a brown …
We explored the plasticity of different white adipose tissue depots in acquiring a brown …
Cholinergic modulation of striatal microcircuits
N Abudukeyoumu, T Hernandez‐Flores… - European Journal of …, 2019 - Wiley Online Library
The purpose of this review is to bridge the gap between earlier literature on striatal
cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the …
cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the …
Photoreceptor signaling: supporting vision across a wide range of light intensities
For decades, photoreceptors have been an outstanding model system for elucidating basic
principles in sensory transduction and biochemistry and for understanding many facets of …
principles in sensory transduction and biochemistry and for understanding many facets of …
The evolution of the GPCR signaling system in eukaryotes: modularity, conservation, and the transition to metazoan multicellularity
The G-protein-coupled receptor (GPCR) signaling system is one of the main signaling
pathways in eukaryotes. Here, we analyze the evolutionary history of all its components …
pathways in eukaryotes. Here, we analyze the evolutionary history of all its components …
Neuronal G protein-gated K+ channels
H Luo… - American Journal of …, 2022 - journals.physiology.org
G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …
[HTML][HTML] Longitudinal genome-wide association studies of milk production traits in Holstein cattle using whole-genome sequence data imputed from medium-density …
J Teng, D Wang, C Zhao, X Zhang, Z Chen, J Liu… - Journal of Dairy …, 2023 - Elsevier
Longitudinal traits, such as milk production traits in dairy cattle, are featured by having
phenotypic values at multiple time points, which change dynamically over time. In this study …
phenotypic values at multiple time points, which change dynamically over time. In this study …
G protein–dependent and G protein–independent signaling pathways and their impact on cardiac function
DG Tilley - Circulation research, 2011 - Am Heart Assoc
G protein-coupled receptors signal through a variety of mechanisms that impact cardiac
function, including contractility and hypertrophy. G protein–dependent and G protein …
function, including contractility and hypertrophy. G protein–dependent and G protein …
Subtype-dependent regulation of Gβγ signalling
G protein-coupled receptors (GPCRs) transmit information to the cell interior by transducing
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …