No longer viewed as a metabolic waste product and cause of muscle fatigue, a
contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in …

Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

Herein, we use lessons learned in exercise physiology and metabolism to propose that
augmented lactate production ('lactagenesis'), initiated by gene mutations, is the reason and …

Abstract Since Otto Warburg reported the 'addiction'of cancer cells to fermentative glycolysis,
a metabolic pathway that provides energy and building blocks, thousands of studies have …

Tumor metabolism consists of complex interactions between oxygenation states,
metabolites, ions, the vascular network and signaling cascades. Accumulation of lactate …

CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely
expressed in human tumors and plays a central role in the progression of many cancers by …

CD147 is involved in many physiological functions, such as lymphocyte responsiveness,
spermatogenesis, implantation, fertilization and neurological functions at early stages of …

CD147 also known as EMMPRIN, basigin, and HAb18G, is a single-chain type I
transmembrane protein shown to be overexpressed in aggressive human cancers of CNS …

Once thought to be a waste product of oxygen limited (anaerobic) metabolism, lactate is now
known to form continuously under fully oxygenated (aerobic) conditions. Lactate shuttling …

The main obstacles that lead to clinical failure in cancer treatment are the development of
resistant to chemotherapy and a rise in invasive characteristics in cancer tumor cells due to …