Protein–protein interactions (PPIs) are of pivotal importance in the regulation of biological
systems and are consequently implicated in the development of disease states. Recent work …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

The potential utility of synthetic macrocycles (MCs) as drugs, particularly against low-
druggability targets such as protein-protein interactions, has been widely discussed. There …

Protein–protein interactions (PPIs) have emerged as important and challenging targets in
chemical biology and medicinal chemistry. The main difficulty encountered in the discovery …

A strategy is outlined for the design of hand-twisted helical crystals. The starting point in the
exercise is the one-dimensional (1D) plastic crystal, 1, 4-dibromobenzene, which is then …

Over the past decade, protein–protein interactions (PPIs) have gone from being neglected
as 'undruggable'to being considered attractive targets for the development of therapeutics …

The von Hippel–Lindau tumor suppressor protein is the substrate binding subunit of the VHL
E3 ubiquitin ligase, which targets hydroxylated α subunit of hypoxia inducible factors (HIFs) …

A wide range of methods are currently available for determining the dissociation constant
between a protein and interacting small molecules. However, most of these require access …

Protein-protein interactions (PPIs) underlie the majority of biological processes, signaling,
and disease. Approaches to modulate PPIs with small molecules have therefore attracted …

Protein–protein interactions (PPIs) are important targets for the development of chemical
probes and therapeutic agents. From the initial discovery of the existence of hot spots at PPI …