After the discovery of zinc deficiency in the 1960s, it soon became clear that zinc is essential
for the function of the immune system. Zinc ions are involved in regulating intracellular …

Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency
as well as zinc excess result in severe disturbances in immune cell numbers and activities …

Zinc fingers are small protein domains in which zinc plays a structural role contributing to the
stability of the domain. Zinc fingers are structurally diverse and are present among proteins …

The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer
predisposition syndromes. PTEN is a phosphatase that can act on both polypeptide and …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase
important in B‐lymphocyte development, differentiation, and signaling. Btk is a member of …

Morphologic polarity is necessary for chemotaxis of mammalian cells. As a probe of
intracellular signals responsible for this asymmetry, the pleckstrin homology domain of the …

Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K)
enzymes whose inositol lipid products are key mediators of intracellular signaling. Different …

Phosphorylation plays a central role in regulating the activation and signalling lifetime of
protein kinases A, B (also known as Akt) and C. These kinases share three conserved …

Pleckstrin homology (PH) domains are small protein modules of around 120 amino acids
found in many proteins involved in cell signalling, cytoskeletal rearrangement and other …