Over the past few decades, biologists have identified key molecular signatures associated
with a wide range of human cancers. Recently, animal models have been particularly useful …

Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …

Tumor organoids maintain cell–cell interactions, heterogeneity, microenvironment, and drug
response of the sample they originate from. Thus, there is increasing interest in develo** …

Invasion and metastasis of aggressive breast cancer cells are the final and fatal steps during
cancer progression. Clinically, there are still limited therapeutic interventions for aggressive …

Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during
cancer progression, and is the least understood genetically. Clinically, there are still limited …

Leukaemia inhibitory factor (LIF) has been recently identified as a p53 target gene, which
mediates the role of p53 in maternal implantation under normal physiological conditions …

There is increasing evidence that some cancers are hierarchically organized, sustained by a
relatively rare population of cancer-initiating cells (C-ICs). Although the capacity to initiate …

Here, I propose that cancer stem cells (CSCs) would be equivalent to para-embryonic stem
cells (p-ESCs), derived from adult cells de-re-programmed to a ground state. p-ESCs would …

Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and
progression of many cancer types, including leukemia. However, the ID1 protein has not yet …

Despite advances in therapy, glioblastoma remains an incurable disease with a dismal
prognosis. Recent studies have implicated cancer stem cells within glioblastoma (glioma …