Fundamental aspects of phase-separated biomolecular condensates
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …
understanding in much of molecular, cell, and developmental biology. There is an urgent …
Expanding the molecular language of protein liquid–liquid phase separation
Understanding the relationship between a polypeptide sequence and its phase separation
has important implications for analysing cellular function, treating disease and designing …
has important implications for analysing cellular function, treating disease and designing …
When data are lacking: Physics-based inverse design of biopolymers interacting with complex, fluid phases
J Methorst, N van Hilten, A Hoti, KS Stroh… - Journal of Chemical …, 2024 - ACS Publications
Biomolecular research traditionally revolves around comprehending the mechanisms
through which peptides or proteins facilitate specific functions, often driven by their …
through which peptides or proteins facilitate specific functions, often driven by their …
Prediction of phase separation propensities of disordered proteins from sequence
Phase separation is thought to be one possible mechanism governing the selective cellular
enrichment of biomolecular constituents for processes such as transcriptional activation …
enrichment of biomolecular constituents for processes such as transcriptional activation …
Predicting heteropolymer interactions: Demixing and hypermixing of disordered protein sequences
Cells contain multiple condensates which spontaneously form due to the heterotypic
interactions between their components. Although the proteins and disordered region …
interactions between their components. Although the proteins and disordered region …
Sequence complexity and monomer rigidity control the morphologies and aging dynamics of protein aggregates
R Takaki, D Thirumalai - Proceedings of the National Academy of …, 2024 - pnas.org
Understanding the biophysical basis of protein aggregation is important in biology because
of the potential link to several misfolding diseases. Although experiments have shown that …
of the potential link to several misfolding diseases. Although experiments have shown that …
[HTML][HTML] Balancing thermodynamic stability, dynamics, and kinetics in phase separation of intrinsically disordered proteins
G Zhang, X Chu - The Journal of Chemical Physics, 2024 - pubs.aip.org
Intrinsically disordered proteins (IDPs) are prevalent participants in liquid–liquid phase
separation due to their inherent potential for promoting multivalent binding. Understanding …
separation due to their inherent potential for promoting multivalent binding. Understanding …
Asymmetry in polymer–solvent interactions yields complex thermoresponsive behavior
We introduce a lattice framework that incorporates elements of Flory–Huggins solution
theory and the q-state Potts model to study the phase behavior of polymer solutions and …
theory and the q-state Potts model to study the phase behavior of polymer solutions and …
Effects of charge asymmetry on the liquid–liquid phase separation of polyampholytes and their condensate properties
Liquid–liquid phase separation (LLPS) is the mechanism underlying the formation of bio-
molecular condensates which are important compartments regulating intra-and extra …
molecular condensates which are important compartments regulating intra-and extra …
[HTML][HTML] Mesoscale properties of biomolecular condensates emerging from protein chain dynamics
Biomolecular condensates form by phase separation of biological polymers. The cellular
functions of the resulting membraneless organelles are closely linked to their physical …
functions of the resulting membraneless organelles are closely linked to their physical …